Macromolecular Bioscience

Cover image for Vol. 16 Issue 7

July 2016

Volume 16, Issue 7

Pages 937–1095

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      Macromol. Biosci. 7/2016 (page 937)

      Kousuke Tsuchiya and Keiji Numata

      Version of Record online: 4 JUL 2016 | DOI: 10.1002/mabi.201670025

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      Front Cover: Unique telechelic-type polypeptides were synthesized by the facile and environmentally benign enzymatic polymerization using a telechelic initiator. The telechelic polyalanine was found to assemble into long nanofibers by the antiparallel β-sheet structure whereas the conventional linear polyalanine showed a granule-like morphology. Further details can be found in the article by Kousuke Tsuchiya, Keiji Numata on page 1001.

  2. Back Cover

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    1. Macromol. Biosci. 7/2016 (page 1096)

      Urara Hasegawa, Tengjiao Wang, Jerry J. Y. Chen, Hiroshi Uyama and André J. van der Vlies

      Version of Record online: 4 JUL 2016 | DOI: 10.1002/mabi.201670028

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      Back Cover: Micelles prepared by self-assembly of an amphiphilic furoxan-bearing block copolymer release nitric oxide in response to cysteine and potentiate the anti-proliferative effect of ibuprofen in human colon cancer cells. Further details can be found in the article by U. Hasegawa, T. J. Wang, J. Y. Chen, H. Uyama, and A. J. van der Vlies on page 1009.

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    1. Masthead: Macromol. Biosci. 7/2016

      Version of Record online: 4 JUL 2016 | DOI: 10.1002/mabi.201670026

  4. Contents

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    1. Contents: Macromol. Biosci. 7/2016 (pages 939–943)

      Version of Record online: 4 JUL 2016 | DOI: 10.1002/mabi.201670027

  5. Feature Articles

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    1. Polymer–Graphene Nanocomposite Materials for Electrochemical Biosensing (pages 944–957)

      Peter Sobolewski, Magdalena Piwowarczyk and Mirosława El Fray

      Version of Record online: 18 MAY 2016 | DOI: 10.1002/mabi.201600081

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      Biosensors can take advantage of and translate the potential of the information provided by the “-omics” into the clinic. Recent developments in polymer science, nanotechnology, and carbon-nanomaterials—graphene in particular—offer a great deal of promise in achieving the goal of an ideal biosensor: sensitive and specific, fast, affordable, and simple.

  6. Reviews

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    1. Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy (pages 958–977)

      Anwarul Hasan, Renae Waters, Boustany Roula, Rahbani Dana, Seif Yara, Toubia Alexandre and Arghya Paul

      Version of Record online: 8 MAR 2016 | DOI: 10.1002/mabi.201500396

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      Biofunctional materials offer a potential approach to manipulate stem cell behavior in vitro and in vivo. A variety of bioactive materials can be synthesized in combination with stem cells to engineer the new generation of biomedical therapeutics to repair and regenerate damaged tissues, in particular cardiac tissues. This article explores the emerging techniques with biofunctional materials to enhance stem cell function in heart and for cardiac tissue engineering.

  7. Communications

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    1. Pinosylvin-Based Polymers: Biodegradable Poly(Anhydride-Esters) for Extended Release of Antibacterial Pinosylvin (pages 978–983)

      Stephan Bien-Aime, Weiling Yu and Kathryn E. Uhrich

      Version of Record online: 13 APR 2016 | DOI: 10.1002/mabi.201500454

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      Pinosylvin, analog of resveratrol, possesses antibacterial bioactivities against common foodborne bacteria. To prolong pinosylvin's valuable antibacterial effects and further its usage as a natural food preservative, the natural stilbenoid is chemically incorporated into a poly(anhydride-ester) backbone. Physicochemical and thermal testing reveal successful synthesis while in vitro hydrolytic degradation of the polymer confirms sustained bioactive release of pinosylvin over 40 d.

    2. DOPC-Detergent Conjugates: Fusogenic Carriers for Improved In Vitro and In Vivo Gene Delivery (pages 984–989)

      Philippe Pierrat, Anne Casset, Dimitri Kereselidze, Marie Lux, Françoise Pons and Luc Lebeau

      Version of Record online: 15 MAR 2016 | DOI: 10.1002/mabi.201600012

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      Cationic lipids are widely used synthetic carriers for in vitro gene delivery. Cationic phospholipid-detergent conjugates are designed so they display intrinsic fusogenic properties, thus enhancing cellular uptake of the corresponding DNA lipoplexes. 1,2-Dioleoyl-sn-glycero-3-phosphocholine-C12E4 conjugate 10 is a highly efficient trans­fection vector for both in vitro gene delivery and in vivo gene delivery. Administration of lipoplexes in mouse airway results in high transgene expression while inflammatory response that characterizes lipid-mediated gene transfer is not observed.

    3. Visible Light and pH Responsive Polymer-Coated Mesoporous Silica Nanohybrids for Controlled Release (pages 990–994)

      Guojie Wang, Jie Dong, Tingting Yuan, Juchen Zhang, Lei Wang and Hao Wang

      Version of Record online: 3 MAR 2016 | DOI: 10.1002/mabi.201600008

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      Visible light and pH responsive nanocarriers based on polymer-coated mesoporous silica nanohybrids have been developed by electrostatic self-assembly. Visible light and acid stimulation can induce the nanopores unsealed. The synergistic effect of the stimuli on the efficient release of anticancer drugs from the nanohybrids endows the system with great potential for cancer therapy.

    4. Formation of Highly Aligned Collagen Nanofibers by Continuous Cyclic Stretch of a Collagen Hydrogel Sheet (pages 995–1000)

      Eunryel Nam, Won Chul Lee and Shoji Takeuchi

      Version of Record online: 2 MAY 2016 | DOI: 10.1002/mabi.201600068

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      A collagen sheet with highly aligned collagen fibers is fabricated by continuous cyclic stretch. The collagen fibers are aligned perpendicularly to the direction of the stretch. Corneal stromal cells and smooth muscle cells on the collagen sheet show alignment along the fibers without the stretch during culture. Thus, the sheet can be a suitable scaffold for use in regenerative medicine.

  8. Full Papers

    1. Top of page
    2. Cover Picture
    3. Back Cover
    4. Masthead
    5. Contents
    6. Feature Articles
    7. Reviews
    8. Communications
    9. Full Papers
    1. Papain-Catalyzed Chemoenzymatic Synthesis of Telechelic Polypeptides Using Bis(Leucine Ethyl Ester) Initiator (pages 1001–1008)

      Kousuke Tsuchiya and Keiji Numata

      Version of Record online: 7 MAR 2016 | DOI: 10.1002/mabi.201600005

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      Telechelic type polypeptides are prepared by chemoenzymatic polymerization of glycine or alanine using papain in the presence of a telechelic initiator. The telechelic polyglycine and polyalanine show crystalline structures based on Polyglycine II and antiparallel β-sheet, respectively. Long nanofibrils are formed by the telechelic polyalanine, which differs from the morphology prepared from a conventional linear polyalanine.

    2. Furoxan-Bearing Micelles for Nitric Oxide Delivery (pages 1009–1018)

      Urara Hasegawa, Tengjiao Wang, Jerry J. Y. Chen, Hiroshi Uyama and André J. van der Vlies

      Version of Record online: 8 MAR 2016 | DOI: 10.1002/mabi.201500401

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      Nitric oxide (NO)-releasing polymeric micelles bearing furoxan moieties are prepared from an amphiphilic block copolymer consisting of a hydrophobic furoxan-bearing block and a hydrophilic poly(N-acryloylmorpholine) block. The micelles release NO in the presence of cysteine and potentiate the anti-proliferative effect of ibuprofen, a nonsteroidal anti-inflammatory drug, in human colon cancer cells.

    3. Bioactive Nanocomposite Poly (Ethylene Glycol) Hydrogels Crosslinked by Multifunctional Layered Double Hydroxides Nanocrosslinkers (pages 1019–1026)

      Heqin Huang, Jianbin Xu, Kongchang Wei, Yang J. Xu, Chun Kit K. Choi, Meiling Zhu and Liming Bian

      Version of Record online: 8 APR 2016 | DOI: 10.1002/mabi.201600054

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      A bioactive nanocomposite poly (ethylene glycol) (PEG) hydrogel crosslinked polydopamine-coated layered double hydroxide (PD-LDH) nanosheet. The catechol-rich PD-LDH nanosheets not only act as effective nanocrosslinkers reinforcing the hydrogel, but also afford robust bioactivity and bioadhesion via the cortical-mediated couplings. Furthermore, these hydrogels also promote the sequestration of proteins and support the osteogenic differentiation of human mesenchymal stem cells without any further biofunctionalization.

    4. Poly(l-Lactic Acid)/Gelatin Fibrous Scaffold Loaded with Simvastatin/Beta-Cyclodextrin-Modified Hydroxyapatite Inclusion Complex for Bone Tissue Regeneration (pages 1027–1038)

      Jung Bok Lee, Ji Eun Kim, Daniel A. Balikov, Min Soo Bae, Dong Nyoung Heo, Donghyun Lee, Hyun Joon Rim, Deok-Won Lee, Hak-Joon Sung and Il Keun Kwon

      Version of Record online: 21 MAR 2016 | DOI: 10.1002/mabi.201500450

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      β-Cyclodextrin grafted hydroxyapatite nanoparticles are coated onto the surface of PLLA/gelatin fibrous scaffolds by an inclusion complex system. To provide a favorable microenvironment for bone tissue regeneration, simvastatin, an osteoinductive drug, is loaded into β-cyclodextrin within the hydroxyapatite nanoparticle.

    5. Microspheres Assembled from Chitosan-Graft-Poly(lactic acid) Micelle-Like Core–Shell Nanospheres for Distinctly Controlled Release of Hydrophobic and Hydrophilic Biomolecules (pages 1039–1047)

      Xufeng Niu, Zhongning Liu, Jiang Hu, Kunal J. Rambhia, Yubo Fan and Peter X. Ma

      Version of Record online: 14 MAR 2016 | DOI: 10.1002/mabi.201600020

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      Micelles in microspheres are assembled from chitosan-graft-poly(lactic acid) (CS-g-PLA) copolymers. Hydrophobic biomolecules (green dots) are bound to hydrophobic cores of CS-g-PLA micelle-like nanospheres and hydrophilic biomolecules (red dots) are bound to hydrophilic shells and interspaces of CS-g-PLA nanospheres.

    6. Bioactive, Elastic, and Biodegradable Emulsion Electrospun DegraPol Tube Delivering PDGF-BB for Tendon Rupture Repair (pages 1048–1063)

      Olivera Evrova, Joanna Houska, Manfred Welti, Eliana Bonavoglia, Maurizio Calcagni, Pietro Giovanoli, Viola Vogel and Johanna Buschmann

      Version of Record online: 13 APR 2016 | DOI: 10.1002/mabi.201500455

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      A new emulsion electrospun double-layered tube based on an elastic and biodegradable block copolymer (DegraPol®), delivering proteins in a sustained manner has been developed. Aimed to be used for tendon rupture repair application, it allows sustained delivery of bioactive PDGF-BB, thus promoting tenocyte proliferation in vitro.

    7. Enzymatic Modification of Soluble Cyanophycin Using the Type II Peptidyl Arginine Deiminase from Oryctolagus cuniculus (pages 1064–1071)

      Lars Wiefel and Alexander Steinbüchel

      Version of Record online: 8 MAR 2016 | DOI: 10.1002/mabi.201500433

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      The purified type II peptidyl arginine deiminase of Oryctolagus cuniculus is used for the first enzymatic modification of arginine residues of the biopolymer cyanophycin and its dipeptides. About 4 mol% of the polymer side chains and 7.5 mol% of the dipeptides can be converted to citrulline. An inhibitory effect for free citrulline can be identified.

    8. Elastic Light Tunable Tissue Adhesive Dendrimers (pages 1072–1082)

      Gao Feng, Ivan Djordjevic, Vishal Mogal, Richard O'Rorke, Oleksandr Pokholenko and Terry W. J. Steele

      Version of Record online: 8 APR 2016 | DOI: 10.1002/mabi.201600033

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      This paper describes a bioadhesive system aimed at reconnection of soft tissues. The bioadhesive is based on poly amido amine dendrimer, grafted with UV-sensitive, diazirine,-4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzyl bromide. The dendrimer formulation adheres to hydrated tissues upon low power UV activation. The adhesion strength and mechanical modulus are dependent on grafting concentration and the energy of UV light.

    9. Chondrocyte Generation of Cartilage-Like Tissue Following Photoencapsulation in Methacrylated Polysaccharide Solution Blends (pages 1083–1095)

      James W. S. Hayami, Stephen D. Waldman and Brian G. Amsden

      Version of Record online: 9 APR 2016 | DOI: 10.1002/mabi.201500465

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      Photo-cross-linked hydrogels formed from solution blends of methacrylated glycol chitosan, methacrylated hyaluronic acid (MHA), and methacrylated chondroitin sulfate (MCS) are assessed for their ability to support chondrocyte viability and extracellular matrix (ECM) accumulation in static culture. MHAMCS hydrogels possess equilibrium moduli appropriate for load-bearing soft tissue regeneration while also providing the best environment for chondrocyte ECM production.

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