Macromolecular Bioscience

Cover image for Vol. 9 Issue 11

November 10, 2009

Volume 9, Issue 11

Pages 1043–1142

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Feature Article
    5. Full Papers
    1. Macromol. Biosci. 11/2009

      Travis J. Klein, Simone C. Rizzi, Johannes C. Reichert, Nicole Georgi, Jos Malda, Wouter Schuurman, Ross W. Crawford and Dietmar W. Hutmacher

      Version of Record online: 3 NOV 2009 | DOI: 10.1002/mabi.200990023

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      Cover: Hydrogel constructs are being developed to incorporate zonal properties important for articular cartilage function. Distinct cell populations printed in layered structures maintain desired localization, co-cultures develop cell alignment, and gels of varying stiffness accumulate differing amounts of matrix. Further details can be found in the Feature Article by T. J. Klein, S. C. Rizzi, J. C. Reichert, N. Georgi, J. Malda, W. Schuurman, R. W. Crawford, and D. W. Hutmacher*on page 1049.

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Feature Article
    5. Full Papers
    1. Macromol. Biosci. 11/2009 (pages 1043–1046)

      Version of Record online: 3 NOV 2009 | DOI: 10.1002/mabi.200990024

  3. Feature Article

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Feature Article
    5. Full Papers
    1. Strategies for Zonal Cartilage Repair using Hydrogels (pages 1049–1058)

      Travis J. Klein, Simone C. Rizzi, Johannes C. Reichert, Nicole Georgi, Jos Malda, Wouter Schuurman, Ross W. Crawford and Dietmar W. Hutmacher

      Version of Record online: 8 SEP 2009 | DOI: 10.1002/mabi.200900176

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      Hydrogel systems have been developed to allow for systematic manipulation of properties, such as stiffness, degradability, and cell interactions. The diverse range of hydrogel properties combined with advanced fabrication techniques can be used to engineer cartilage with depth-dependent properties like those in normal articular cartilage. These constructs have potential for regenerative treatment of cartilage defects.

  4. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Feature Article
    5. Full Papers
    1. Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis (pages 1059–1068)

      Tiancheng Lu, Jing Sun, Xuexi Chen, Peibiao Zhang and Xiabin Jing

      Version of Record online: 17 AUG 2009 | DOI: 10.1002/mabi.200900134

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      Folate-conjugated micelles for the selective delivery of hydrophobic molecules are developed. They have potential to deliver drugs into folate-receptor over-expressing cancer cells HeLa via folate receptors mediated endocytosis in vitro and in vivo. These micelle systems can be used in the delivery of anticancer drugs and their selective target to cancer cells.

    2. Surface Coating with a Thermoresponsive Copolymer for the Culture and Non-Enzymatic Recovery of Mouse Embryonic Stem Cells (pages 1069–1079)

      Xian Jun Loh, Jiansheng Gong, Makoto Sakuragi, Takashi Kitajima, Mingzhe Liu, Jun Li and Yoshihiro Ito

      Version of Record online: 15 JUN 2009 | DOI: 10.1002/mabi.200900081

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      Temperature-induced non-enzymatic detachment of mouse embryonic stem cells is demonstrated for cells cultured on coatings of a thermally responsive triblock copolymer, poly(N-isopropylacrylamide)-block-poly[(R)-3-hydroxybutyrate]-block-poly(N-isopropylacrylamide) and gelatin, and gelatin alone. Cells adhere at 37 °C, but can be detached by cooling at 4 °C. The embryonic stem cells remained undifferentiated after culture on the gelatin/copolymer-coated surfaces.

    3. The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(ε-caprolactone)] Copolymers (pages 1080–1089)

      Jing Mao and Zhihua Gan

      Version of Record online: 24 JUL 2009 | DOI: 10.1002/mabi.200900104

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      An amphiphilic diblock copolymer PG-b-PCL with well-controlled block length was synthesized by sequential anionic ring-opening copolymerization and hydroxyl deprotection reaction. The pendant hydroxyl groups along the hydrophilic PG blocks show great influences on drug-loading capacity, controlled release, and biodegradation of micelles and microspheres which were self-assembled or fabricated from PG-b-PCL copolymers. The results indicate the potentials of PG-b-PCL micelles in biomedical application.

    4. Hyperbranched Polyamidoamines Containing β-Cyclodextrin for Controlled Release of Chlorambucil (pages 1090–1097)

      Yuanyuan Zhou, Zhe Guo, Yongwen Zhang, Wei Huang, Yongfeng Zhou and Deyue Yan

      Version of Record online: 14 JUL 2009 | DOI: 10.1002/mabi.200900110

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      HPMAs with various amounts of β-cyclodextrin were synthesized and used as drug carriers. The anti-cancer drug chlorambucil was selected and loaded into them. The release experiments in vitro showed that the presence of β-CD can appropriately slow CLB release from HPMA-β-CDs and adjust the ratio of CLB released in total drug loading.

    5. Preparation of Glycogen-Based Polysaccharide Materials by Phosphorylase-Catalyzed Chain Elongation of Glycogen (pages 1098–1104)

      Hironori Izawa, Mutsuki Nawaji, Yoshiro Kaneko and Jun-ichi Kadokawa

      Version of Record online: 27 JUL 2009 | DOI: 10.1002/mabi.200900106

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      Glycogen-based polysaccharide gel materials were prepared by phosphorylase-catalyzed chain elongation of glycogen using glucose 1-phosphate. The resulting solution from the enzymatic reaction gradually turned into a hydrogel, which was lyophilized to afford the glycogen-based xerogel. The xerogel was subjected to film formation and re-hydrogelation with appropriate techniques.

    6. Affinity Study of Novel Gelatin Cell Carriers for Fibronectin (pages 1105–1115)

      Sandra Van Vlierberghe, Els Vanderleyden, Peter Dubruel, Filip De Vos and Etienne Schacht

      Version of Record online: 23 JUL 2009 | DOI: 10.1002/mabi.200900043

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      The affinity of gelatin type A and B for fibronectin was evaluated using surface plasmon resonance, quartz crystal microbalance and radiolabeling experiments. The affinity study was performed on both hydrogel films and 3D scaffolds. In addition to quantifying the amount of adsorbed/absorbed Fn, the binding kinetics of Fn and gelatin were evaluated in depth.

    7. Amphiphilic Polymer Nanoparticles: Characterization and Assessment as New Drug Carriers (pages 1116–1126)

      Pranabesh Dutta, Saurabh Shrivastava and Joykrishna Dey

      Version of Record online: 14 AUG 2009 | DOI: 10.1002/mabi.200900135

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      Two amino-acid-derived hydrophobically modified polyelectrolytes were shown to form nanometer-sized aggregates in water. The drug encapsulation and release properties of the aggregates have been investigated.

    8. Protonatable Ionenes for Nucleic Acid Complexation (pages 1127–1134)

      Sean M. Ramirez, John M. Layman and Timothy E. Long

      Version of Record online: 27 JUL 2009 | DOI: 10.1002/mabi.200900137

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      Novel tboc-protected and pH-sensitive protonatable ionenes were synthesized and used to complex plasmid DNA into polyplexes for non-viral gene transfection in human brain microvascular endothelial cells. The protonatable ionenes possessed a buffering range from pH=57. These ionenes were compared to determine the influence of secondary amines in strong polyelectrolytes to elucidate polymer structure/property relationships on transfection.

    9. Antitumor Efficacy of Colon-Specific HPMA Copolymer/9-Aminocamptothecin Conjugates in Mice Bearing Human-Colon Carcinoma Xenografts (pages 1135–1142)

      Song-Qi Gao, Yongen Sun, Pavla Kopečková, C. Matthew Peterson and Jindřich Kopeček

      Version of Record online: 14 AUG 2009 | DOI: 10.1002/mabi.200900147

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      HPMA-copolymer/9-aminocamptothecin (9-AC) conjugates release 9-AC in the colon through aromatic-azo-bond degradation followed by 1,6-elimination. They are effective in the treatment of orthotopic and subcutaneous HT29 human-colon carcinoma models in nu/nu mice. Additionally, a decrease of the systemic toxicity of the conjugate is observed when compared with the free-drug treatment.

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