Macromolecular Bioscience

Cover image for Vol. 9 Issue 9

September 9, 2009

Volume 9, Issue 9

Pages 827–929

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Back Cover
    1. Macromol. Biosci. 9/2009

      Jason D. Ehrick, Matthew R. Luckett, Santoshkumar Khatwani, Yinan Wei, Sapna K. Deo, Leonidas G. Bachas and Sylvia Daunert

      Version of Record online: 27 AUG 2009 | DOI: 10.1002/mabi.200990017

      Thumbnail image of graphical abstract

      Front Cover: Glucose-responsive hydrogels have been prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. These hydrogels demonstrate “accordion”-like dynamic behavior in response to glucose, allowing for controlled transport of molecules across the glucose sensitive hydrogels. Further details can be found in the article by J. D. Ehrick, M. R. Luckett, S. Khatwani, Y. Wei, S. K. Deo, L. G. Bachas, S. Daunert*on page 864.

  2. Contents

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Back Cover
    1. Macromol. Biosci. 9/2009 (pages 827–830)

      Version of Record online: 27 AUG 2009 | DOI: 10.1002/mabi.200990018

  3. Communications

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Back Cover
    1. A Hybrid DNA Aptamer–Dendrimer Nanomaterial for Targeted Cell Labeling (pages 831–835)

      Jing Zhou, Boonchoy Soontornworajit, Jacob Martin, Bruce A. Sullenger, Eli Gilboa and Yong Wang

      Version of Record online: 11 MAY 2009 | DOI: 10.1002/mabi.200900046

      Thumbnail image of graphical abstract

      It is of great interest to develop multifunctional nanomaterials that are smaller but more stable than antibodies for targeted cell labeling. The purpose of this research is to demonstrate that a new type of sub-10 nm hybrid nanomaterial can be readily synthesized with a nucleic acid aptamer and a dendrimer as structural units, and that this nanomaterial can recognize target cells with high binding affinity and specificity.

    2. Ammonium-Based Cellulose Solvents Suitable for Homogeneous Etherification (pages 836–841)

      Sarah Köhler, Tim Liebert and Thomas Heinze

      Version of Record online: 21 JUL 2009 | DOI: 10.1002/mabi.200900156

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      Melts of inorganic and organic salts are known as cellulose solvents and reaction medium for the homogeneous conversion of the polymer. However, they are rather expensive and most of them contain large amounts of water, which may induce side reactions. Melts of simple trialkylammonium salts could be an inexpensive alternative. Thus, trialkylammonium carboxylates were synthesized and studied as potential solvents and reaction medium for the homogeneous etherication of cellulose.

  4. Full Papers

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Back Cover
    1. Preparation of Size Tunable Amphiphilic Poly(amino acid) Nanoparticles (pages 842–848)

      Hyungjin Kim, Takami Akagi and Mitsuru Akashi

      Version of Record online: 6 MAY 2009 | DOI: 10.1002/mabi.200800367

      Thumbnail image of graphical abstract

      Hydrophobically modified γ-poly(glutamic acid) (γ-hPGA) was synthesized by grafting hydrophobic amino acids to γ-PGA. To regulate the size of γ-hPGA NPs, the γ-hPGA copolymers dissolved in DMSO were added to various concentration of NaCl solution. The size of the NPs increased with increasing NaCl concentration. The size of γ-hPGA NPs could be easily controlled by altering the NaCl concentration without any structural change of the NPs.

    2. Properties and Bioapplications of Blended Cellulose and Corn Protein Films (pages 849–856)

      Quanling Yang, Ang Lue, Haisong Qi, Yunxia Sun, Xianzheng Zhang and Lina Zhang

      Version of Record online: 21 APR 2009 | DOI: 10.1002/mabi.200900008

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      Films that consist of a blend of cellulose and corn protein overcome the disadvantages of the pure protein films (friable and water-soluble), and exhibit improved proliferation of HeLa cells (Fig. a,b), a good optical transmittance (Fig c), and mechanical properties. The blend films with features of safeness, biocompatibility, and biodegradability have promising applications in the field of biomaterials.

    3. Preparation and Characterization of Novel Quaternized Cellulose Nanoparticles as Protein Carriers (pages 857–863)

      Yongbo Song, Jinping Zhou, Qian Li, Yi Guo and Lina Zhang

      Version of Record online: 15 APR 2009 | DOI: 10.1002/mabi.200800371

      Thumbnail image of graphical abstract

      Quaternized cellulose (QC) nanoparticles as novel protein carriers were successfully prepared by ionic crosslinking of QC with sodium tripolyphosphate. QC nanoparticles displayed high loading efficiency and capacity for BSA and their physicochemical properties and release profile could be easily adjusted.

    4. Glucose Responsive Hydrogel Networks Based on Protein Recognition (pages 864–868)

      Jason D. Ehrick, Matthew R. Luckett, Santoshkumar Khatwani, Yinan Wei, Sapna K. Deo, Leonidas G. Bachas and Sylvia Daunert

      Version of Record online: 11 MAY 2009 | DOI: 10.1002/mabi.200800337

      Thumbnail image of graphical abstract

      A glucose-responsive hydrogel has been synthesized by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates “accordion”-like dynamic response to glucose, thus rendering the transport of marker molecules across the hydrogel sensitive to glucose.

    5. Reverse Thermal Organogelation of Poly(ethylene glycol)-Polypeptide Diblock Copolymers in Chloroform (pages 869–874)

      Yun Young Choi, Yuri Jeong, Min Kyung Joo and Byeongmoon Jeong

      Version of Record online: 21 APR 2009 | DOI: 10.1002/mabi.200900095

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      We discuss the reverse thermal gelation of methoxy-aminopoly(ethylene glycol)-polypeptide block copolymer chloroform solutions that undergo a sol-to-gel transition as the temperature increases. This is the opposite behavior to traditional organogels. The polypeptide can take on a β-sheet or α-helix morphology, and the particular morphology, which is influenced by the chain length of the methoxy- aminopoly(ethylene glycol) component influences the morphology of the gel: spherical micelles/short tubular structure or a fibrous structure.

    6. Enzyme-Free Quinone Crosslinking Reaction for Proteins: A Macromolecular Characterization Study Using Gelatin (pages 875–883)

      Asao Yamauchi, Yoshiro Hatanaka, Tetsuo Muro and Osamu Kobayashi

      Version of Record online: 11 MAY 2009 | DOI: 10.1002/mabi.200900032

      Thumbnail image of graphical abstract

      Gelatin was quinone crosslinked in aqueous phase by treatment with HQ and a simple copper(II) salt under oxygen atmosphere. The hydrogel and the film of the crosslinked protein were thermally stable and mechanically strong. The crosslink formation is discussed in consideration of a copper(II) ion catalyzed oxidation of HQ and the protein/quinone adducts.

    7. Electrospun Hybrid Nanofibers Based on Chitosan or N-Carboxyethylchitosan and Silver Nanoparticles (pages 884–894)

      Hristo Penchev, Dilyana Paneva, Nevena Manolova and Iliya Rashkov

      Version of Record online: 6 MAY 2009 | DOI: 10.1002/mabi.200900003

      Thumbnail image of graphical abstract

      Novel nanofibrous materials containing silver nanoparticles were electrospun from chitosan or N-carboxyethylchitosan solutions in formic acid by reactive electrospinning in the presence of poly(ethylene oxide). Water-stable mats were obtained by cross-linking with glutaraldehyde. The obtained materials are promising as wound healing dressings or antibacterial filters.

    8. Shear-reversibly Crosslinked Alginate Hydrogels for Tissue Engineering (pages 895–901)

      Honghyun Park, Sun-Woong Kang, Byung-Soo Kim, David J. Mooney and Kuen Yong Lee

      Version of Record online: 6 MAY 2009 | DOI: 10.1002/mabi.200800376

      Thumbnail image of graphical abstract

      Injectable alginate hydrogels with shear-reversible gelation behavior can be prepared by combination crosslinking using cell-crosslinking and ionic crosslinking techniques. The addition of a small quantity of calcium ions can decrease the number of cells which are required to form cell-crosslinked hydrogels without changing the shear reversibility. Gels are useful to engineer cartilage tissues in vivo.

    9. Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin (pages 902–910)

      Lixia Ren, Lihong He, Tongchen Sun, Xia Dong, Yongming Chen, Jin Huang and Chun Wang

      Version of Record online: 18 JUN 2009 | DOI: 10.1002/mabi.200900021

      Thumbnail image of graphical abstract

      PEG-grafted copolymers with protonizable segments were synthesized and novel supramolecular physical hydrogels were obtained by threading PEG grafts with α-CDs in aqueous solution. It was found that the gel/sol transformation was affected by polymer concentration, polymer chain uniformity, PEG graft densities, temperature and pH of solution. Encapsulating and releasing BSA using the hydrogels were explored.

    10. Adhesion of Human U937 Monocytes to Nitrogen-Rich Organic Thin Films: Novel Insights into the Mechanism of Cellular Adhesion (pages 911–921)

      Pierre-Luc Girard-Lauriault, Florina Truica-Marasescu, Alain Petit, Hong T. Wang, Patrick Desjardins, John Antoniou, Fackson Mwale and Michael R. Wertheimer

      Version of Record online: 26 MAY 2009 | DOI: 10.1002/mabi.200800359

      Thumbnail image of graphical abstract

      U937 monocytes were cultured on N-rich organic coatings with well-characterised surface chemistries, deposited by plasmaand vacuum ultraviolet photo-polymerisation. By comparing those materials that trigger cell-adhesion, we demonstrated the dominant role of primary amines in the adhesion mechanism. RT-PCR analyses of adhering cells displayed a transient expression of cytokines, but a more sustained expression of genes implicated in the adhesion and retention of monocytes.

    11. Covalent Immobilization of Subtilisin A onto Thin Films of Maleic Anhydride Copolymers (pages 922–929)

      Mariana Tasso, Ana L. Cordeiro, Katrin Salchert and Carsten Werner

      Version of Record online: 26 MAY 2009 | DOI: 10.1002/mabi.200900005

      Thumbnail image of graphical abstract

      We present a versatile strategy for the immobilization of Subtilisin A to surfaces using different types of maleic anhydride copolymer coatings for the covalent anchorage of the enzyme. The performance of the immobilized enzyme was shown to be influenced by the physicochemical characteristics of the polymer support. Higher amounts and activities of the protease were obtained on hydrophilic, swollen (PEMA) coatings.

  5. Back Cover

    1. Top of page
    2. Cover Picture
    3. Contents
    4. Communications
    5. Full Papers
    6. Back Cover
    1. Macromol. Biosci. 9/2009

      Hyungjin Kim, Takami Akagi and Mitsuru Akashi

      Version of Record online: 27 AUG 2009 | DOI: 10.1002/mabi.200990019

      Thumbnail image of graphical abstract

      Back Cover: Amphiphilic graft copolymers composed of poly(γ-glutamic acid) (γ-PGA) and hydrophobic amino acid (HAA) were prepared. By regulating the aggregation of the amphiphilic graft copolymers, the size of the nanoparticles was easily controlled. Further details can be found in the article by H. Kim, T. Akagi, M. Akashi*on page 842.

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