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Monolithic Media Prepared Via Electron Beam Curing for Proteins Separation and Flow-Through Catalysis

Authors

  • Rajendar Bandari,

    1. Leibniz Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstraße 15, D-04318 Leipzig, Germany
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  • Wolfgang Knolle,

    1. Leibniz Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstraße 15, D-04318 Leipzig, Germany
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  • Andrea Prager-Duschke,

    1. Leibniz Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstraße 15, D-04318 Leipzig, Germany
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  • Hans-Jürgen Gläsel,

    1. Leibniz Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstraße 15, D-04318 Leipzig, Germany
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  • Michael R. Buchmeiser

    Corresponding author
    1. Leibniz Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstraße 15, D-04318 Leipzig, Germany
    2. Institut für Technische Chemie, Universität Leipzig, Linnéstr. 3, D-04103 Leipzig, Germany
    • Leibniz Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstraße 15, D-04318 Leipzig, Germany. Fax: (+49) 341 235 2584
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Abstract

A novel approach to acrylate/methacrylate-based monolithic systems via electron-beam (EB) initiated polymerization is described. The thus obtained monolithic columns were found suitable for the analytical scale separation of proteins. The novel concept of monolith synthesis was successfully extended to the synthesis of large diameter (20 mm × 300 mm id) monolithic columns applying EB irradiation in a pulsed mode. A homogeneous structure in terms of particle size and porous structure was again realized throughout the entire monolith. Functionalization of the monolithic columns was accomplished via copolymerization of a functional monomer, N,N-dipyrid-2-ylmethacryl amide. The thus obtained functional monoliths were loaded with Pd (II) and used for the Heck-coupling of styrene with iodobenzene in a continuous process.

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