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Parallel Synthesis of Polymer Libraries Using Atom Transfer Radical Polymerization (ATRP)

  1. Mohammed J. Nasrullah,
  2. Dean C. Webster*

Article first published online: 17 MAR 2009

DOI: 10.1002/macp.200800578

Issue

Macromolecular Chemistry and Physics

Macromolecular Chemistry and Physics

Volume 210, Issue 8, pages 640–650, April 22, 2009

Additional Information

How to Cite

Nasrullah, M. J. and Webster, D. C. (2009), Parallel Synthesis of Polymer Libraries Using Atom Transfer Radical Polymerization (ATRP). Macromol. Chem. Phys., 210: 640–650. doi: 10.1002/macp.200800578

Author Information

  1. Center for Nanoscale Science and Engineering, Department of Coating and Polymeric Materials, North Dakota State University, PO Box 6050, Department 2760, Fargo, North Dakota 58108 USA

*Center for Nanoscale Science and Engineering, Department of Coating and Polymeric Materials, North Dakota State University, PO Box 6050, Department 2760, Fargo, North Dakota 58108 USA. Fax: (+701) 231 8439

Publication History

  1. Issue published online: 14 APR 2009
  2. Article first published online: 17 MAR 2009
  3. Manuscript Accepted: 5 FEB 2009
  4. Manuscript Revised: 4 FEB 2009
  5. Manuscript Received: 25 NOV 2008

Funded by

  • Office of Naval Research. Grant Numbers: N00014-07-1-1099, N00014-06-1-0952

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Keywords:

  • atom transfer radical polymerization;
  • combinatorial chemistry;
  • high-throughput screening;
  • polystyrene;
  • poly(t-butyl acrylate);
  • reversible addition fragmentation chain transfer (RAFT)

Abstract

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Parallel atom transfer radical polymerization (ATRP) of styrene and t-butyl acrylate (t-BA) was investigated. A series of ATRP polymerizations were carried out in parallel with varying targeted molecular weight (equation image) and showed excellent reproducibility of equation image, polydispersity, and conversion. In addition, polymerizations were done to determine the effect of inhibitor on styrene polymerization, yielding similar results. In synthesizing a library of polymers having varying equation image using ATRP, polymers having lower equation image reach their target values earlier and the others continue to react under heating, resulting in peak broadening for the low equation image polymers. Reinitiation experiments indicated that termination reactions were taking place resulting in “dead” polymer chains which were unable to reinitiate polymerization.

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