Mimic of Protein: A Highly pH-Sensitive and Thermoresponsive Polyampholyte

Authors

  • Yuqiong Xia,

    1. Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
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  • Min Gao,

    1. Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
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  • Ye Chen,

    1. Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
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  • Xinru Jia,

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    • Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
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  • Dehai Liang

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    • Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
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Abstract

As a mimic of protein, a polyampholyte-based material should be able to duplicate the properties and functions of protein. A polyampholyte that is highly sensitive to both pH and temperature under physiological conditions is obtained when 80% butylamide-terminated poly(amidoamine) dentron is grafted to the backbone of styrene and maleic anhydride. The phase separation occurs at 33.7 °C at pH = 6.20, while the transition point increases to 43.9 °C at pH = 6.30. The superior performance is the consequence of the cooperative interactions among basic, acidic, and thermoresponsive groups. The polyampholyte with a suitable isoelectric point provides a platform for the development of multifunctional materials for biomedical applications.

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