Get access

Modification of Microbial Polymalic Acid With Hydrophobic Amino Acids for Drug-Releasing Nanoparticles

Authors

  • Alberto Lanz-Landázuri,

    1. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain
    Search for more papers by this author
  • Montserrat García-Alvarez,

    Corresponding author
    1. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain
    • Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain.
    Search for more papers by this author
  • José Portilla-Arias,

    1. Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Search for more papers by this author
  • Antxon Martínez de Ilarduya,

    1. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain
    Search for more papers by this author
  • Eggehard Holler,

    1. Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Search for more papers by this author
  • Julia Ljubimova,

    1. Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Search for more papers by this author
  • Sebastián Muñoz-Guerra

    1. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028, Barcelona, Spain
    Search for more papers by this author

Abstract

Microbial poly(β,L-malic acid) was modified with either L-leucine ethyl ester (L) or L-phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis of the side chain ester group followed by cleavage of the main chain. Spherical nanoparticles with diameters ranging between 70 and 230 nm were prepared from these copolymers by the dialysis-precipitation method. No alteration of the cell viability was observed after incubation of these nanoparticles in different cell lines. Anticancer drugs temozolomide and doxorubicin were encapsulated in the nanoparticles. Temozolomide was released within several hours whereas doxorubicin took several weeks to be completely liberated.

Get access to the full text of this article

Ancillary