Controlled PEGylation of PLA-Based Nanoparticles

Authors

  • Raffaele Ferrari,

    1. Department of Chemistry, Materials and Chemical Engineering “Giulio Natta,” Politecnico di Milano, Via Luigi Mancinelli 7, 20131 Milano, Italy
    Current affiliation:
    1. R. Ferrari and Y. Yu have contributed equally to this work.
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  • Yingchuan Yu,

    1. Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli Str. 10, 8093 Zurich, Switzerland
    Current affiliation:
    1. R. Ferrari and Y. Yu have contributed equally to this work.
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  • Marco Lattuada,

    1. Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli Str. 10, 8093 Zurich, Switzerland
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  • Giuseppe Storti,

    1. Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli Str. 10, 8093 Zurich, Switzerland
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  • Massimo Morbidelli,

    1. Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli Str. 10, 8093 Zurich, Switzerland
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  • Davide Moscatelli

    Corresponding author
    1. Department of Chemistry, Materials and Chemical Engineering “Giulio Natta,” Politecnico di Milano, Via Luigi Mancinelli 7, 20131 Milano, Italy
    • Department of Chemistry, Materials and Chemical Engineering “Giulio Natta,” Politecnico di Milano, Via Luigi Mancinelli 7, 20131 Milano, Italy.
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Abstract

The controlled synthesis of degradable nanoparticles (NPs) made from a brush copolymer constituted of a 2-hydroxyethyl methacrylate (HEMA) backbone with PEG and PLA pendants both tunable in length and composition has been developed. Using ring-opening polymerization (ROP) of L,L–lactide, vinyl end-functionalized PLA macromonomers were produced and then copolymerized with HEMA–PEG macromonomers. Narrow dispersed PEGylated NPs with size down to 25 nm with different PEGylation degree and PEG chain lengths were obtained. Surfactant-free MSSEP in the absence of any solvent was implemented to produce NPs suitable for biomedical applications. The colloidal stability in isotonic solutions of these NPs was investigated and the corresponding critical coagulation concentration (CCC) of the NPs was determined.

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