Dual-Functional PEI–Poly(γ-Cholesterol-l-Glutamate) Copolymer for Drug/Gene Co-delivery (pages 163–170)
Jinkun Zhang, Dailong Fang, Qing Ma, Zhiyao He, Ke Ren, Rui Zhou, Shi Zeng, Bo Li, Lili He, Gu He and Xiangrong Song
Version of Record online: 24 NOV 2013 | DOI: 10.1002/macp.201300551
A series of novel amphiphilic PEI-poly(γ-cholesterol-L-glutamate) (PEI-PCHLG) copolymers are synthesized and characterized. One of PEI-PCHLG copolymers can self-assemble into micelles. The PCHLG block assembles into micelles with high drug entrapment, and the grafted PEI block can act as a hydrophilic section exposed outside the micelles, which are capable of carrying genes. Thus PEI-PCLG copolymers are potential carriers for drug/gene co-delivery.