Effect of Processing Variables on the Morphology of Electrospun Poly[(lactic acid)-co-(glycolic acid)] Nanofibers

Authors

  • Fujuan Liu,

    1. Key Laboratory of Textile Science and Technology, Ministry of Education, Donghua University, Shanghai 201620, China
    2. College of Textiles, Donghua University, Shanghai 201620, China
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  • Rui Guo,

    1. Key Laboratory of Textile Science and Technology, Ministry of Education, Donghua University, Shanghai 201620, China
    2. College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai 201620, China
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  • Mingwu Shen,

    1. Key Laboratory of Textile Science and Technology, Ministry of Education, Donghua University, Shanghai 201620, China
    2. College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai 201620, China
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  • Shanyuan Wang,

    1. Key Laboratory of Textile Science and Technology, Ministry of Education, Donghua University, Shanghai 201620, China
    2. College of Textiles, Donghua University, Shanghai 201620, China
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  • Xiangyang Shi

    Corresponding author
    1. Key Laboratory of Textile Science and Technology, Ministry of Education, Donghua University, Shanghai 201620, China
    2. College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai 201620, China
    • College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai 201620, China.
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Abstract

A systematic study of the effects of equation image, flow rate, voltage, and composition on the morphology of electrospun PLGA nanofibers is reported. It is shown that changes of voltage and flow rate do not appreciably affect the morphology. However, the equation image of PLGA predominantly determines the formation of bead structures. Uniform electrospun PLGA nanofibers with controllable diameters can be formed through optimization. Further, multi-walled carbon nanotubes can be incorporated into the PLGA nanofibers, significantly enhancing their tensile strength and elasticity without compromising the uniform morphology. The variable size, porosity, and composition of the nanofibers are essential for their applications in regenerative medicine.

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