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Clay Nanotube/Poly(methyl methacrylate) Bone Cement Composites with Sustained Antibiotic Release

  1. Wenbo Wei1,
  2. Elshad Abdullayev1,
  3. Anne Hollister2,
  4. David Mills1,
  5. Yuri M. Lvov1,*

Article first published online: 10 FEB 2012

DOI: 10.1002/mame.201100309

Additional Information

How to Cite

Wei, W., Abdullayev, E., Hollister, A., Mills, D. and Lvov, Y. M. (2012), Clay Nanotube/Poly(methyl methacrylate) Bone Cement Composites with Sustained Antibiotic Release. Macromol. Mater. Eng.. doi: 10.1002/mame.201100309

Author Information

  1. 1

    Institute for Micromanufacturing and Biomedical Engineering Department, Louisiana Tech University, Ruston, LA 71270, USA

  2. 2

    Health Science Center, Orthopedics Department, Louisiana State University, Shreveport, LA 71130, USA

*Institute for Micromanufacturing and Biomedical Engineering Department, Louisiana Tech University, Ruston, LA 71270, USA

Publication History

  1. Article first published online: 10 FEB 2012
  2. Manuscript Revised: 2 NOV 2011
  3. Manuscript Received: 14 SEP 2011

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Keywords:

  • antibiotics, bone cements, composites, halloysite, polymeric materials

Abstract

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Orthopedic-grade PMMA bone cement, admixed with prophylactic antibiotics, is widely used in hip and knee replacement surgery. There is a critical need to improve its structural integrity and to control antibiotic release. In this study, clay nanotubes are loaded with the antibiotic gentamicin sulfate and the cement is doped with 5–8 wt% nanotubes. The halloysite nanotubes isolate the drug from the cement monomers and serve as nanocontainers for sustained release of the antibiotic. Gentamicin-loaded clay nanotubes admixed in PMMA cement provide sustained release up to 300–400 h and with enhanced release at cement cracks. The PMMA/halloysite/gentamicin composite tensile strength does not deteriorate as compared with pure cement and its adhesion to bone is significantly increased.

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