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Keywords:

  • biocompatibility;
  • biodegradable;
  • block copolymers;
  • micelles

Abstract

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The structure and formation of micelles of the poly(aspartic acid)-block-polylactide (PAsp-block-PLA) diblock copolymers synthesized here.

Summary: A poly(aspartic acid)-block-polylactide (PAsp-block-PLA) diblock copolymer was synthesized through the polymerization of β-benzyl-L-aspartate-N-carboxyanhydride [Asp(OBzl)-NCA] with amino-terminating polylactide (NH2-PLA) as a macroinitiator. The chain length of the PAsp segment could be easily controlled by changing the monomer/initiator ratio. Dynamic light scattering measurements of PAsp-block-PLA aqueous solutions revealed the formation of polymeric micelles. Changes in the micelles as a function of pH were investigated.