Living Cationic Polymerizations Utilizing an Automated Synthesizer: High-Throughput Synthesis of Polyoxazolines

Authors

  • Richard Hoogenboom,

    1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Martin W. M. Fijten,

    1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Michael A. R. Meier,

    1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Ulrich S. Schubert

    Corresponding author
    1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands
    • Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands. Fax: +31-(0)40-2474186
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Abstract

Living cationic ring-opening polymerizations of 2-ethyl-2-oxazoline and purification of the resulting polymers were performed utilizing an automated synthesizer. Eight polymers (500 mg scale) as well as 40 polymers (150 mg scale) were synthesized in parallel to investigate the reproducibility and the living character of the polymerizations. The poly(2-ethyl-2-oxazoline)s obtained such were characterized by means of 1H NMR spectroscopy, MALDI-TOF mass spectrometry and online gel permeation chromatography.

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