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Atom Transfer Radical Polymerization with Polypeptide Initiators: A General Approach to Block Copolymers of Sequence-Defined Polypeptides and Synthetic Polymers†
Article first published online: 18 JUN 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Macromolecular Rapid Communications
Volume 25, Issue 13, pages 1251–1256, July 2004
How to Cite
Rettig, H., Krause, E. and Börner, H. G. (2004), Atom Transfer Radical Polymerization with Polypeptide Initiators: A General Approach to Block Copolymers of Sequence-Defined Polypeptides and Synthetic Polymers. Macromol. Rapid Commun., 25: 1251–1256. doi: 10.1002/marc.200400140
- Issue published online: 18 JUN 2004
- Article first published online: 18 JUN 2004
- Manuscript Accepted: 13 MAY 2004
- Manuscript Received: 14 APR 2004
- atom transfer radical polymerization (ATRP);
- block copolymers;
- controlled polymerization;
Summary: A novel two-step polymerization strategy allowing the integration of sequence-defined oligopeptides into synthetic polymers has been demonstrated by the successful synthesis of an oligopeptide-block-poly(n-butyl acrylate) copolymer. The approach utilizes a solid-phase supported synthesis of an oligopeptide macroinitiator (SPPS) followed by solution-phase atom transfer radical polymerization (ATRP) initiated by the oligopeptide macroinitiator. The resulting block copolymer exhibited a low (1.19) and a controllable .