A Cyclodextrin Microgel for Controlled Release Driven by Inclusion Effects

Authors

  • Yu-Yang Liu,

    Corresponding author
    1. Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an, 710072, People's Republic of China
    • Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an, 710072, People's Republic of China
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  • Xiao-Dong Fan,

    1. Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an, 710072, People's Republic of China
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  • Tao Kang,

    1. Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an, 710072, People's Republic of China
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  • Le Sun

    1. Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an, 710072, People's Republic of China
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Abstract

Summary: A novel intelligent delivery system based on the environmental dependence of the inclusion effect of β-cyclodextrin (β-CD) with guest molecules, using a β-CD polymer (CDP) microgel as carrier, is proposed. Compared with smart hydrogels, which are driven by the phase-volume transition, controlled release from the CDP microgel is driven by “host-guest” inclusion effects. With the pH-dependent inclusion complexation of methyl orange (MO) with β-CD as a model system, the behavior of the controlled release of a CDP microgel was tested by changing the pH, showing that the mechanism is reasonable.

original image

Schematic illustration of the pH-dependent inclusion complexation of MO with β-CD in the CDP microgel.

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