Comparison of Hyperbranched and Linear Polyglycidol Unimolecular Reverse Micelles as Nanoreactors and Nanocapsules

Authors

  • Kainthan Rajesh Kumar,

    1. Department of Pathology and Laboratory Medicine, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada
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  • Donald E. Brooks

    Corresponding author
    1. Department of Pathology and Laboratory Medicine, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    2. Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC V6T 1Z1, Canada
    • Department of Pathology and Laboratory Medicine, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada. Fax: (604) 822-7635
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Abstract

Summary: Amphiphilic-hyperbranched polyglycidols and a linear analogue were tested for their ability to act as nanoreactors for the unimolecular elimination (E1) reactions of tert-alkyl iodides. Their encapsulation properties were also compared. The linear polymer was found to have very good “unimolecular reverse micellar” characteristics as well, even though the results showed the advantages of a hyperbranched nature over a linear one. Our results stress the need for a direct comparison of branched and linear polymers for any application.

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Amphiphilic polyglycidol unimolecular reverse micelles.

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