Communication

PEO-b-PCL Block Copolymers: Synthesis, Detailed Characterization, and Selected Micellar Drug Encapsulation Behavior

  1. Michael A. R. Meier1,
  2. Sebastianus N. H. Aerts1,
  3. Bastiaan B. P. Staal2,
  4. Mircea Rasa1,
  5. Ulrich S. Schubert1,*

Article first published online: 28 NOV 2005

DOI: 10.1002/marc.200500591

Issue

Macromolecular Rapid Communications

Macromolecular Rapid Communications

Volume 26, Issue 24, pages 1918–1924, December 22, 2005

Additional Information

How to Cite

Meier, M. A. R., Aerts, S. N. H., Staal, B. B. P., Rasa, M. and Schubert, U. S. (2005), PEO-b-PCL Block Copolymers: Synthesis, Detailed Characterization, and Selected Micellar Drug Encapsulation Behavior. Macromolecular Rapid Communications, 26: 1918–1924. doi: 10.1002/marc.200500591

Author Information

  1. 1

    Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands

  2. 2

    Polymer Technology Group, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands

*Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute (DPI), PO Box 513, 5600 MB Eindhoven, The Netherlands.

Publication History

  1. Issue published online: 28 NOV 2005
  2. Article first published online: 28 NOV 2005
  3. Manuscript Accepted: 13 OCT 2005
  4. Manuscript Revised: 10 OCT 2005
  5. Manuscript Received: 25 AUG 2005

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Keywords:

  • block copolymers;
  • combinatorial materials research;
  • drug encapsulation;
  • MALDI-TOF MS;
  • micelles

Abstract

Summary: A series of poly(ethylene glycol)-block-poly(ε-caprolactone) diblock copolymers was synthesized and fully characterized. In particular, MALDI-TOF MS results revealed interesting new insights into their molecular architecture. Small and defined micelles could be prepared from these block copolymers. Utilizing a high-throughput screening approach, it was observed that these micelles are able to encapsulate/solubilize different guest molecules (e.g. drugs) depending on the solubility of the guest in water. Furthermore, it could be proven that a guest is located within a micelle and that these micelles can be utilized as transport vehicles for the encapsulated guest molecules.

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