Communication

Transport of Guest Molecules by Unimolecular Micelles Evidenced in Analytical Ultracentrifugation Experiments

  1. Mircea Rasa,
  2. Michael A. R. Meier,
  3. Ulrich S. Schubert*

Article first published online: 19 JUN 2007

DOI: 10.1002/marc.200700115

Issue

Macromolecular Rapid Communications

Macromolecular Rapid Communications

Volume 28, Issue 13, pages 1429–1433, July 2, 2007

Additional Information

How to Cite

Rasa, M., Meier, M. A. R. and Schubert, U. S. (2007), Transport of Guest Molecules by Unimolecular Micelles Evidenced in Analytical Ultracentrifugation Experiments. Macromolecular Rapid Communications, 28: 1429–1433. doi: 10.1002/marc.200700115

Author Information

  1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, Den Dolech 2, 5600 MB Eindhoven, The Netherlands

*Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, Den Dolech 2, 5600 MB Eindhoven, The Netherlands. Fax: +31 40 247 4186

Publication History

  1. Issue published online: 26 JUN 2007
  2. Article first published online: 19 JUN 2007
  3. Manuscript Accepted: 27 APR 2007
  4. Manuscript Revised: 22 APR 2007
  5. Manuscript Received: 13 FEB 2007

Funded by

  • Dutch Polymer Institute (DPI). Grant Numbers: 360, 604
  • Nederlandse Organisatie for Wetenschappelijk Onderzoek (NWO) (VICI award for USS)
  • Fonds der Chemischen Industrie

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Keywords:

  • analytical ultracentrifugation;
  • core-shell polymers;
  • guest encapsulation;
  • guest transport;
  • molar mass;
  • sedimentation coefficient;
  • unimolecular micelles

Abstract

The ability of star-shaped, block copolymer-based unimolecular micelles to encapsulate and transport guest molecules was studied. Analytical ultracentrifugation studies clearly showed that methyl-orange guest molecules could be encapsulated and transported, together with unimolecular micelles consisting of 5-arm, star-shaped block copolymers with a poly(ethylene glycol) core and a poly(ε-caprolactone) corona. Sedimentation-velocity and equilibrium measurements were performed to determine the sedimentation coefficients, molar masses, and diffusion coefficients of the loaded, unimolecular micelles. It was observed that the transport of guest molecules by unimolecular micelles was a function of the molecular weight of the star-shaped block copolymers and therefore also of their size.

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