Transport of Guest Molecules by Unimolecular Micelles Evidenced in Analytical Ultracentrifugation Experiments

Authors

  • Mircea Rasa,

    1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, Den Dolech 2, 5600 MB Eindhoven, The Netherlands
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  • Michael A. R. Meier,

    1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, Den Dolech 2, 5600 MB Eindhoven, The Netherlands
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  • Ulrich S. Schubert

    Corresponding author
    1. Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, Den Dolech 2, 5600 MB Eindhoven, The Netherlands
    • Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, Den Dolech 2, 5600 MB Eindhoven, The Netherlands. Fax: +31 40 247 4186
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Abstract

The ability of star-shaped, block copolymer-based unimolecular micelles to encapsulate and transport guest molecules was studied. Analytical ultracentrifugation studies clearly showed that methyl-orange guest molecules could be encapsulated and transported, together with unimolecular micelles consisting of 5-arm, star-shaped block copolymers with a poly(ethylene glycol) core and a poly(ε-caprolactone) corona. Sedimentation-velocity and equilibrium measurements were performed to determine the sedimentation coefficients, molar masses, and diffusion coefficients of the loaded, unimolecular micelles. It was observed that the transport of guest molecules by unimolecular micelles was a function of the molecular weight of the star-shaped block copolymers and therefore also of their size.

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