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Intramolecular Click Cycloaddition: An Efficient Room-Temperature Route towards Bioconjugable Polymeric Nanoparticles

Authors

  • Alaitz Ruiz de Luzuriaga,

    1. New Materials Department, CIDETEC, Centre for Electrochemical Technologies, Parque Tecnológico de San Sebastián, Paseo Miramón 196, Donostia-San Sebastián E-20009, Spain
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  • Nerea Ormategui,

    1. New Materials Department, CIDETEC, Centre for Electrochemical Technologies, Parque Tecnológico de San Sebastián, Paseo Miramón 196, Donostia-San Sebastián E-20009, Spain
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  • Hans J. Grande,

    1. New Materials Department, CIDETEC, Centre for Electrochemical Technologies, Parque Tecnológico de San Sebastián, Paseo Miramón 196, Donostia-San Sebastián E-20009, Spain
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  • Ibon Odriozola,

    1. New Materials Department, CIDETEC, Centre for Electrochemical Technologies, Parque Tecnológico de San Sebastián, Paseo Miramón 196, Donostia-San Sebastián E-20009, Spain
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  • José A. Pomposo,

    1. New Materials Department, CIDETEC, Centre for Electrochemical Technologies, Parque Tecnológico de San Sebastián, Paseo Miramón 196, Donostia-San Sebastián E-20009, Spain
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  • Iraida Loinaz

    Corresponding author
    1. New Materials Department, CIDETEC, Centre for Electrochemical Technologies, Parque Tecnológico de San Sebastián, Paseo Miramón 196, Donostia-San Sebastián E-20009, Spain
    • New Materials Department, CIDETEC, Centre for Electrochemical Technologies, Parque Tecnológico de San Sebastián, Paseo Miramón 196, Donostia-San Sebastián E-20009, Spain. Fax: +34 943 30 9136
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Abstract

A highly efficient room-temperature synthetic route to bioconjugable polymeric nanoparticles in the 5–20 nm size range based on single-chain intramolecular click cycloaddition is described. It is illustrated by preparing single-chain cross-linked polymeric NPs from poly[MMA-co-(3-azidopropyl methacrylate)-co-(3-trimethylsilyl-propyn-1-yl methacrylate)] terpolymers using a one-pot procedure and a continuous addition technique. For polymeric NPs with an excess of azide groups, aminoacid/PMMA NPs were easily obtained by performing a second click reaction with propargyl glycine. This versatile and general method opens the way to the synthesis of other kinds of polymeric and bioconjugated NPs beyond those reported in this communication.

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