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Direct Generation of Polymer Films on Copper Surfaces through Azide-Alkyne Cycloaddition Reactions between Peptidomimetic Oligomers

  1. Neel H. Shah,
  2. Kent Kirshenbaum*

Article first published online: 23 APR 2008

DOI: 10.1002/marc.200800042

Issue

Macromolecular Rapid Communications

Macromolecular Rapid Communications

Special Issue: Click Chemistry in Polymer Science

Volume 29, Issue 12-13, pages 1134–1139, July 1, 2008

Additional Information

How to Cite

Shah, N. H. and Kirshenbaum, K. (2008), Direct Generation of Polymer Films on Copper Surfaces through Azide-Alkyne Cycloaddition Reactions between Peptidomimetic Oligomers. Macromolecular Rapid Communications, 29: 1134–1139. doi: 10.1002/marc.200800042

Author Information

  1. Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003-6688, USA

*Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003-6688, USA. Fax: (+1) 212 260 7905

Publication History

  1. Issue published online: 8 JUL 2008
  2. Article first published online: 23 APR 2008
  3. Manuscript Accepted: 28 FEB 2008
  4. Manuscript Received: 18 JAN 2008

Funded by

  • NYU College of Arts and Science Dean's Undergraduate Research Fund

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Keywords:

  • biomaterials;
  • biomimetic;
  • click chemistry;
  • metal coating;
  • peptoids

Abstract

N-substituted glycine oligomers, or peptoids, can be used in conjunction with the copper-catalyzed [3 + 2] cycloaddition of azides and alkynes to generate branched polymer networks. By incorporating both azides and alkynes as side chain functionalities on the oligomer scaffolds, peptoids are able to form cross-linked macromolecular products. The oligomer starting materials are readily associated onto copper metal sheets, allowing for localized cross-link proliferation which in turn generates thin film polymer coatings. This novel procedure provides a direct method for the chemical modification of metal surfaces and the formation of mechanically robust sequence-specific polymer networks.

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