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Polymersome/Silica Capsules by ‘Click’-Chemistry

Authors

  • Wolfgang H. Binder,

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    1. Martin-Luther University Halle-Wittenberg, Faculty of Natural Sciences II (Chemistry and Physics), Institute of Chemistry/Division Technical and Macromolecular Chemistry, Heinrich-Damerowstr. 4/12, 06120 Halle Saale, Germany
    • Martin-Luther University Halle-Wittenberg, Faculty of Natural Sciences II (Chemistry and Physics), Institute of Chemistry/Division Technical and Macromolecular Chemistry, Heinrich-Damerowstr. 4/12, 06120 Halle Saale, Germany.
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  • Robert Sachsenhofer

    1. Martin-Luther University Halle-Wittenberg, Faculty of Natural Sciences II (Chemistry and Physics), Institute of Chemistry/Division Technical and Macromolecular Chemistry, Heinrich-Damerowstr. 4/12, 06120 Halle Saale, Germany
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Abstract

Polyisobutylene/poly(ethylene oxide) diblock copolymers (PIBn-PEOm) with variable block-lengths (n = 40, 75; m = 31, 52) have been prepared by a combination of living polymerization cationic methods and azide/alkyne ‘click’ chemistry. Allyl-telechelic PIBs are transformed into the respective telechelic PIB-azides (PIB-N3) by a quantitative procedure. Coupling of the PIB-N3 to acetylene-telechelic PEO-polymers is then quantitatively achieved by a CuI-mediated cycloaddition reaction. The resulting diblock copolymers reveal lamellar structures in solution at concentrations up to 35 wt.-%, whereas polymersomes are formed at lower concentrations. The resulting polymersomes can be silicified under inclusion of nanoparticles to generate micrometer-sized, multifunctional capsules with a silica shell.

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