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Communication
Synthesis of Folic Acid Functionalized PLLA-b-PPEGMA Nanoparticles for Cancer Cell Targeting
Article first published online: 2 MAR 2009
DOI: 10.1002/marc.200800771
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Hu, F., Neoh, K. G. and Kang, E.-T. (2009), Synthesis of Folic Acid Functionalized PLLA-b-PPEGMA Nanoparticles for Cancer Cell Targeting. Macromol. Rapid Commun., 30: 609–614. doi: 10.1002/marc.200800771
Publication History
- Issue published online: 9 APR 2009
- Article first published online: 2 MAR 2009
- Manuscript Accepted: 14 JAN 2009
- Manuscript Received: 9 DEC 2008
Keywords:
- atom transfer radical polymerization (ATRP);
- folic acid;
- nanoparticles;
- poly(ethylene glycol);
- targeted delivery
Abstract
Poly(L-lactic acid)-block-poly(poly(ethylene glycol) monomethacrylate) (PLLA-b-PPEGMA) has been prepared by the ring-opening polymerization of lactide with a double-headed initiator, 2-hydroxyethyl 2′-methyl-2′-bromopropionate (HMBP), followed by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate (PEGMA). PLLA-b-PPEGMA nanoparticles with encapsulated Fe3O4 are prepared by a solvent evaporation/extraction technique, and then further functionalized with folic acid, a cancer targeting ligand. Our results show that such functionalized PLLA-b-PPEGMA nanoparticles have good potential as carriers for targeted drug delivery in cancer treatment.