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Ring-Opening Metathesis Polymerization-Based Synthesis of CaCO3 Nanoparticle-Reinforced Polymeric Monoliths for Tissue Engineering

Authors

  • Franziska Weichelt,

    1. Leibniz-Institut für Oberflächenmodifizierung e. V. IOM, Permoserstrasse 15, D-04318 Leipzig, Germany
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  • Bernhard Frerich,

    1. Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Universitätsklinikum Rostock, Schillingallee 35, D-18057 Rostock, Germany
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  • Solvig Lenz,

    1. Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Universitätsklinikum Rostock, Schillingallee 35, D-18057 Rostock, Germany
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  • Stefanie Tiede,

    1. Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Universitätsklinikum Rostock, Schillingallee 35, D-18057 Rostock, Germany
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  • Michael R. Buchmeiser

    Corresponding author
    1. Institut für Polymerchemie, Lehrstuhl für Makromolekulare Stoffe und Faserchemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany
    2. Institut für Textilchemie und Chemiefasern, Körschtalstrasse 26, D-73770 Denkendorf, Germany
    • Institut für Polymerchemie, Lehrstuhl für Makromolekulare Stoffe und Faserchemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569 Stuttgart, Germany, Fax: +49 (0) 711 685 64050.
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Abstract

Porous monolithic materials have been prepared via ring-opening metathesis polymerization from norborn-2-ene and a 7-oxanorborn-2-ene-based cross-linker in the presence of porogenic solvents (i.e., 2-propanol and toluene) and norborn-2-enephosphonate surface-modified CaCO3 nanoparticles, using the 3rd-generation Grubbs-initiator RuCl2(Py)2(IMesH2)(CHPh). The experimental setup and the conditions chosen allowed for the manufacturing of polymeric monoliths characterized by a homogeneous distribution of the inorganic nanoparticles throughout the polymeric monolith. Depending on the nanoparticle content, the macropore diameters could be varied in the 30–120 µm regime. Noteworthy, the addition of nanoparticles did not affect the phase separation-triggered formation of the monolithic matrix nor the meso- and microporosity as evidenced by N2-adsorption experiments.

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