Get access

A Water-Soluble Polycarbonate With Dimethylamino Pendant Groups Prepared by Enzyme-Catalyzed Ring-Opening Polymerization

Authors

  • Xiaojin Zhang,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China, Fax: +86-27-68754509
    Search for more papers by this author
  • Mengmeng Cai,

    1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China, Fax: +86-27-68754509
    Search for more papers by this author
  • Zhenlin Zhong,

    Corresponding author
    1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China, Fax: +86-27-68754509
    • Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China, Fax: +86-27-68754509.
    Search for more papers by this author
  • Renxi Zhuo

    Corresponding author
    1. Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China, Fax: +86-27-68754509
    • Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China, Fax: +86-27-68754509.
    Search for more papers by this author

Abstract

A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted ring-opening polymerization (ROP) of DMATC with Sn(Oct)2 as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym-435 as a catalyst to give water-soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability.

Ancillary