Synthesis of β-Cyclodextrin Containing Copolymer via “Click” Chemistry and Its Self-Assembly in the Presence of Guest Compounds

Authors

  • Jianxiang Zhang,

    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Fax: +1 734 647 2110
    2. Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, P.R. China
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  • Kristin Ellsworth,

    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Fax: +1 734 647 2110
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  • Peter X. Ma

    Corresponding author
    1. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Fax: +1 734 647 2110
    2. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    3. Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA
    4. Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    • Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Fax: +1 734 647 2110.
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Abstract

We report the synthesis of a hydrophilic copolymer with one polyethylene glycol (PEG) block and one β-cyclodextrin (β-CD) containing block by a “click” reaction between azido-substituted β-CD and propargyl flanking copolymer. 1H NMR study suggested a highly efficient conjugation of β-CD units by this approach. The obtained copolymer was used as a host macromolecule to construct assemblies in the presence of hydrophobic guests. For assemblies containing a hydrophobic polymer, their size can be simply adjusted by simply changing the content of hydrophobic component. By serving as a guest molecule, hydrophobic drugs can also be loaded accompanying the formation of nanoparticles, and the drug payload is releasable. Therefore, the copolymer synthesized herein can be employed as a carrier for drug delivery.

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