Communication

Combining Modular Ligation and Supramolecular Self-Assembly for the Construction of Star-Shaped Macromolecules

  1. Ozcan Altintas1,
  2. Thierry Muller2,
  3. Elise Lejeune1,3,
  4. Oliver Plietzsch2,
  5. Stefan Bräse2,3,*,
  6. Christopher Barner-Kowollik1,3,*

Article first published online: 17 APR 2012

DOI: 10.1002/marc.201200019

Issue

Macromolecular Rapid Communications

Macromolecular Rapid Communications

Volume 33, Issue 11, pages 977–983, June 14, 2012

Additional Information

How to Cite

Altintas, O., Muller, T., Lejeune, E., Plietzsch, O., Bräse, S. and Barner-Kowollik, C. (2012), Combining Modular Ligation and Supramolecular Self-Assembly for the Construction of Star-Shaped Macromolecules. Macromol. Rapid Commun., 33: 977–983. doi: 10.1002/marc.201200019

Author Information

  1. 1

    Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76128 Karlsruhe, Germany

  2. 2

    Institut für Organische Chemie and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany

  3. 3

    Soft Matter Synthesis Laboratory, Institut für Biologische Grenzflächen I, Karlsruhe Institute of Technology (KIT), Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

*Institut für Organische Chemie and Center for Functional Nanostructures (CFN), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.

Publication History

  1. Issue published online: 5 JUN 2012
  2. Article first published online: 17 APR 2012
  3. Manuscript Revised: 13 FEB 2012
  4. Manuscript Received: 10 JAN 2012

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Keywords:

  • copper-catalyzed azide–alkyne cycloaddition (CuAAC);
  • cyanuric acid;
  • dynamic light scattering;
  • graft Hamilton wedge;
  • hydrogen bonding;
  • modular ligation;
  • nitroxide-mediated radical polymerization (NMP);
  • self-assembly;
  • star-shaped polymer;
  • supramolecular chemistry

Abstract

A well-defined random copolymer of styrene (S) and chloromethylstyrene (CMS) featuring lateral chlorine moieties with an alkyne terminal group is prepared (P(S-co-CMS), equation image = 5500 Da, PDI = 1.13). The chloromethyl groups are converted into Hamilton wedge (HW) entities (P(S-co-HWS), equation image = 6200 Da, PDI = 1.13). The P(S-co-HWS) polymer is subsequently ligated with tetrakis(4-azidophenyl)methane to give HW-functional star-shaped macromolecules (P(S-co-HWS))4, equation image = 25 100 Da, PDI = 1.08). Supramolecular star-shaped copolymers are then prepared via self-assembly between the HW-functionalized four-arm star-shaped macromolecules (P(S-co-HW))4 and cyanuric acid (CA) end-functionalized PS (PS–CA, equation image = 3700 Da, PDI = 1.04), CA end-functionalized poly(methyl methacrylate) (PMMA–CA, equation image = 8500 Da, PDI = 1.13) and CA end-functionalized polyethylene glycol (PEG–CA, equation image = 1700 Da, PDI = 1.05). The self-assembly is monitored by 1H NMR spectroscopy and light scattering analyses.

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