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Polyoxazolines for Nonfouling Surface Coatings — A Direct Comparison to the Gold Standard PEG

Authors

  • Rupert Konradi,

    Corresponding author
    1. BASF SE, Advanced Materials and Systems Research, 67056 Ludwigshafen, Germany
    • BASF SE, Advanced Materials and Systems Research, 67056 Ludwigshafen, Germany.
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  • Canet Acikgoz,

    1. Laboratory for Surface Science and Technology, Department of Materials, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
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  • Marcus Textor

    1. Laboratory for Surface Science and Technology, Department of Materials, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
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Abstract

The prevention of surface fouling is becoming increasingly important for the development of anti-infective medical implants, biosensors with improved signal-to-noise ratios, and low-fouling membranes to name a few examples. We review a direct comparison of poly(ethylene glycol), the gold standard polymer to impart surfaces with nonfouling properties, to an alternative polymer, poly(2-methyl-2-oxazoline) (PMOXA), and show that both polymers are equally excellent in rendering surfaces nonfouling while PMOXA coatings are more stable in oxidative environments. We discuss prerequisites for the fabrication of nonfouling surface coatings and implications for the polymer choice according to application requirements.

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