Reactive Graphene Oxide Nanosheets: A Versatile Platform for the Fabrication of Graphene Oxide–Biomolecule/Polymer Nanohybrids

Authors

  • Li Qun Xu,

    1. Department of Chemical & Biomolecular Engineering, National University of Singapore, 119260, Singapore
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  • Bin Zhang,

    1. Institute of Applied Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China
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  • Yu Chen,

    Corresponding author
    1. Institute of Applied Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China
    • Institute of Applied Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
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  • Koon-Gee Neoh,

    1. Department of Chemical & Biomolecular Engineering, National University of Singapore, 119260, Singapore
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  • En-Tang Kang,

    Corresponding author
    1. Department of Chemical & Biomolecular Engineering, National University of Singapore, 119260, Singapore
    • Department of Chemical & Biomolecular Engineering, National University of Singapore, 119260, Singapore
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  • Guo Dong Fu

    1. School of Chemistry and Chemical Engineering, Southeast University, Jiangning District, Nanjing, Jiangsu Province, 211189, P. R. China
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Abstract

Graphene oxide (GO) nanosheets can be functionalized with reactive pentafluorophenyl ester via esterification of the carboxylic groups. The resulting reactive GO nanosheets provide a versatile platform for grafting of amino-containing polymers or biomolecules via ester–amine coupling. Coupling of poly[(9,9-dioctylfluorene)-alt-(4-amino-phenylcarbazole)] (PFCz-NH2), amino-terminated hyperbranched polyglycerol (HPG-NH2), and lysozyme (Lyz) was illustrated. The Al/GO-g-PFCz/ITO sandwich thin-film device exhibits bistable electrical switching and rewritable memory effects. The GO-g-Lyz nanohybrids exhibit high bactericidal efficacy against S. aureus and E. coli, while the GO-g-HPG nanohybrids exhibit reduced cytotoxicity toward 3T3 fibroblasts.

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