Photo-Degradable, Protein–Polyelectrolyte Complex-Coated, Mesoporous Silica Nanoparticles for Controlled Co-Release of Protein and Model Drugs

Authors

  • Xuejuan Wan,

    Corresponding author
    1. Institute of Advanced Materials, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China; Key Laboratory for Advanced Materials of Ministry of Education, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, P. R. China
    • Institute of Advanced Materials, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, P. R. China; Key Laboratory for Advanced Materials of Ministry of Education, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, P. R. China
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  • Tao Liu,

    1. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
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  • Jinming Hu,

    1. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
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  • Shiyong Liu

    Corresponding author
    1. CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
    • CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
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Abstract

The fabrication of photo-degradable, protein–polyelectrolyte complex (PPC)-coated, mesoporous silica nanoparticles (MSNs) and their controlled co-release of protein and model drugs is reported. Random copolymers composed of oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA), and a photolabile o-nitrobenzyl-containing monomer, 5-(2′-(dimethylamino)ethoxy)-2-nitrobenzyl methacrylate (DENBMA), are first anchored onto the MSNs and then quaternary aminated, to obtain positively charged P(OEGMA-co-TENBMA) which exhibits photo-induced charge conversion characteristics. PPCs consisting of P(OEGMA-co-TENBMA) and the protein bovine serum albumin (BSA) are utilized as capping agents for the nanopores of the MSNs. Upon UV irradiation, charge conversion of P(OEGMA-co-TENBMA) can lead to the disruption of PPCs on MSNs and co-release of BSA and rhodamine B by electrostatic repulsion.

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