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Biodegradable Microparticles with Surface Dimples as a Bi-Modal Imaging Contrast Agent

Authors

  • Mi Ri Kim,

    1. Division of Advanced Materials Engineering, Kongju National University, Cheonan 331-717, Korea
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  • Yong Taik Lim,

    Corresponding author
    1. Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, Korea
    • Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, Korea.
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  • Kuk Young Cho

    Corresponding author
    1. Division of Advanced Materials Engineering, Kongju National University, Cheonan 331-717, Korea
    • Division of Advanced Materials Engineering, Kongju National University, Cheonan 331-717, Korea
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Abstract

Fabrication of physically engineered colloids and their application to the biological fields is emerging importance because of their potential to provide an enhanced performance without altering the chemical properties of biomaterials used. A facile approach is reported to fabricate sub-10-μm-sized PLGA microparticle with small dimples covering the surface by droplet imprinting. Optical and magnetic resonance bioimaging agents are easily co-encapsulated inside the microparticles to obtain a bi-modal imaging agent. Cell internalization efficacy of dimpled particles in DC 2.4 cell is enhanced compared with conventional smooth round-shaped colloids. Our result indicates that morphology-controlled microparticles show promise as a cell labeling with improved cell interaction.

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