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Radiolabeled Nanogels for Nuclear Molecular Imaging

Authors

  • Smriti Singh,

    1. Interactive Materials Research–DWI an der RWTH Aachen e.V. and Institute Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany
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  • Bahar Bingöl,

    1. Interactive Materials Research–DWI an der RWTH Aachen e.V. and Institute Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany
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  • Agnieszka Morgenroth,

    1. Department of Nuclear Medicine, RWTH Aachen University, Pauwelsstr.30, 52074 Aachen, Germany
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  • Felix M. Mottaghy,

    1. Department of Nuclear Medicine, RWTH Aachen University, Pauwelsstr.30, 52074 Aachen, Germany
    2. Department of Nuclear Medicine, Maastricht University Medical Center (MUMC+), P. Debeylaan 25, 6229 HX Maastricht, The Netherlands
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  • Martin Möller,

    Corresponding author
    1. Interactive Materials Research–DWI an der RWTH Aachen e.V. and Institute Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany
    • Interactive Materials Research–DWI an der RWTH Aachen e.V. and Institute Technical and Macromolecular Chemistry, RWTH Aachen University, Forckenbeckstr. 50, 52074 Aachen, Germany
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  • Jörn Schmaljohann

    Corresponding author
    1. Department of Nuclear Medicine, RWTH Aachen University, Pauwelsstr.30, 52074 Aachen, Germany
    • Department of Nuclear Medicine, RWTH Aachen University, Pauwelsstr.30, 52074 Aachen, Germany.
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Abstract

An efficient and simple synthesis approach to form stable 68Ga-labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well-defined spherical shape with a diameter of 290 ± 50 nm. The radionuclide 68Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these 68Ga-nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging.

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