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Polypeptoids by Living Ring-Opening Polymerization of N-Substituted N-Carboxyanhydrides from Solid Supports

Authors

  • Niklas Gangloff,

    1. Professur für Makromolekulare Chemie, Department Chemie und Lebensmittelchemie, Technische Universität Dresden, 01062 Dresden, Germany
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  • Corinna Fetsch,

    1. Professur für Polymere Funktionswerkstoffe, Fakultät Chemie und Pharmazie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany
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  • Robert Luxenhofer

    Corresponding author
    1. Professur für Makromolekulare Chemie, Department Chemie und Lebensmittelchemie, Technische Universität Dresden, 01062 Dresden, Germany
    2. Professur für Polymere Funktionswerkstoffe, Fakultät Chemie und Pharmazie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany
    • Professur für Makromolekulare Chemie, Department Chemie und Lebensmittelchemie, Technische Universität Dresden, 01062 Dresden, Germany.
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Abstract

The nucleophilic living ring-opening polymerization of N-substituted glycine N-carboxyanhydrides using solid-phase synthesis resins is reported. By variation of experimental parameters, products with near Poisson distributions are obtained. As opposed to reversible deactivation radical polymerization, the living polymerization is demonstrated to be viable to high monomer conversion and through multiple monomer addition steps. Successful preparation of a multiblock copolypeptoid is proof for a highly living and robust character of the solid-phase peptoid polymerization.

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