Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3-hydroxyalkanoate) (pages 362–368)
Julien Babinot, Estelle Renard, Benjamin Le Droumaguet, Jean-Michel Guigner, Simona Mura, Julien Nicolas, Patrick Couvreur and Valérie Langlois
Article first published online: 12 DEC 2012 | DOI: 10.1002/marc.201200692
A simple and straightforward method to produce poly(3-hydroxyalkanoate)-based (PHA) multicompartment micelles is presented. Thiol-ene addition is used to efficiently synthesize perfluorooctyl and poly(ethylene glycol)-grafted PHA. These copolymers are shown to self-assemble into multicompartment micelles upon nanoprecipitation in water by cryo-transmission electron microscopy. Moreover, their in vitro cytocompatibility is investigated.