Determination of drugs and drug-like compounds in different samples with direct analysis in real time mass spectrometry

Authors

  • Elena S. Chernetsova,

    Corresponding author
    1. Research and Educational Center of the Peoples' Friendship University of Russia, Miklucho-Maklay st., Bldg. 8/2, 117198 Moscow, Russia
    • Research and Educational Center of the Peoples' Friendship University of Russia, Miklucho-Maklay st., Bldg. 8/2, 117198 Moscow, Russia.
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  • Gertrud E. Morlock

    1. Institute of Food Chemistry, University of Hohenheim, Garbenstr. 28, 70599 Stuttgart, Germany
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Abstract

Direct analysis in real time (DART), a relatively new ionization source for mass spectrometry, ionizes small-molecule components from different kinds of samples without any sample preparation and chromatographic separation. The current paper reviews the published data available on the determination of drugs and drug-like compounds in different matrices with DART-MS, including identification and quantitation issues. Parameters that affect ionization efficiency and mass spectra composition are also discussed. © 2011 Wiley Periodicals, Inc., Mass Spec Rev 30:875–883, 2011

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