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The role of mass spectrometry in the analysis of vitamin D compounds

Authors

  • Rose M. Gathungu,

    1. Barnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115
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  • Caroline C. Flarakos,

    1. Barnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115
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  • G. Satyanarayana Reddy,

    1. Epimer LLC, 1 Valley View Drive, North Smithfield, Rhode Island
    2. Department of Chemistry, Brown University, Providence, Rhode Island
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  • Paul Vouros

    Corresponding author
    1. Barnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115
    • Barnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
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Abstract

This review highlights the superseding role of mass spectrometry in the structural characterization and quantitation of vitamin D compounds in comparison to other analytical methods (e.g., UV, bioassays) that lack the sensitivity and specificity of mass spectrometry. After a short introduction to the biochemistry of vitamin D compounds, an overview of the current techniques to characterize and quantitate vitamin D compounds is given with emphasis on the contribution of mass spectrometry. © 2012 Wiley Periodicals, Inc., Mass Spec Rev 32:72–86, 2013

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