Looking back into the future: 30 years of metabolomics at TNO
Article first published online: 29 APR 2013
© 2013 Wiley Periodicals, Inc.
Mass Spectrometry Reviews
Volume 32, Issue 5, pages 399–415, September/October 2013
How to Cite
van der Greef, J., van Wietmarschen, H., van Ommen, B. and Verheij, E. (2013), Looking back into the future: 30 years of metabolomics at TNO. Mass Spectrom. Rev., 32: 399–415. doi: 10.1002/mas.21370
- Issue published online: 23 AUG 2013
- Article first published online: 29 APR 2013
- Manuscript Revised: 21 NOV 2012
- Manuscript Accepted: 21 NOV 2012
- Manuscript Received: 26 JUN 2012
- systems biology;
- pattern recognition;
- analytical chemistry
Metabolites have played an essential role in our understanding of life, health, and disease for thousands of years. This domain became much more important after the concept of metabolism was discovered. In the 1950s, mass spectrometry was coupled to chromatography and made the technique more application-oriented and allowed the development of new profiling technologies. Since 1980, TNO has performed system-based metabolic profiling of body fluids, and combined with pattern recognition has led to many discoveries and contributed to the field known as metabolomics and systems biology. This review describes the development of related concepts and applications at TNO in the biomedical, pharmaceutical, nutritional, and microbiological fields, and provides an outlook for the future. © 2013 Wiley Periodicals, Inc. Rapid Commun. Mass Spectrom. 32: 399–415, 2013.