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Advances in coupling microfluidic chips to mass spectrometry

Authors

  • Xiaojun Feng,

    1. Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics—Hubei Bioinformatics and Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
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  • Bi-Feng Liu,

    1. Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics—Hubei Bioinformatics and Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
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  • Jianjun Li,

    Corresponding author
    1. Human Health Therapeutics, National Research Council Canada, Ottawa, Ontario
    • Correspondence to: Xin Liu, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

      E-mail: xliu@mail.hust.edu.cn

      Correspondence to: Jianjun Li, Human Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada K1A 0R6.

      E-mail: jianjun.li@nrc-cnrc.gc.ca

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  • Xin Liu

    Corresponding author
    1. Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics—Hubei Bioinformatics and Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
    • Correspondence to: Xin Liu, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

      E-mail: xliu@mail.hust.edu.cn

      Correspondence to: Jianjun Li, Human Health Therapeutics, National Research Council Canada, Ottawa, ON, Canada K1A 0R6.

      E-mail: jianjun.li@nrc-cnrc.gc.ca

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Abstract

Microfluidic technology has shown advantages of low sample consumption, reduced analysis time, high throughput, and potential for integration and automation. Coupling microfluidic chips to mass spectrometry (Chip-MS) can greatly improve the overall analytical performance of MS-based approaches and expand their potential applications. In this article, we review the advances of Chip-MS in the past decade, covering innovations in microchip fabrication, microchips coupled to electrospray ionization (ESI)-MS and matrix-assisted laser desorption/ionization (MALDI)-MS. Development of integrated microfluidic systems for automated MS analysis will be further documented, as well as recent applications of Chip-MS in proteomics, metabolomics, cell analysis, and clinical diagnosis. © 2014 Wiley Periodicals, Inc. Mass Spec Rev 34: 535–557, 2015.

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