Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations

Authors

  • Eugene N. Nikolaev,

    Corresponding author
    1. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
    2. Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
    3. Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia
    4. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia
    • Correspondence to: Eugene Nikolaev, Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskij pr. 38 k. 2, 119334 Moscow, Russia. E-mail: ennikolaev@rambler.ru

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  • Yury I. Kostyukevich,

    1. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
    2. Moscow Institute of Physics and Technology, Dolgoprudnyi, Moscow Region, Russia
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  • Gleb N. Vladimirov

    1. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
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Abstract

Fourier transform ion cyclotron resonance (FT ICR) mass spectrometer offers highest resolving power and mass accuracy among all types of mass spectrometers. Its unique analytical characteristics made FT ICR important tool for proteomics, metabolomics, petroleomics, and investigation of complex mixtures. Signal acquisition in FT ICR MS takes long time (up to minutes). During this time ion–ion interaction considerably affects ion motion and result in decreasing of the resolving power. Understanding of those effects required complicated theory and supercomputer simulations but culminated in the invention of the ion trap with dynamic harmonization which demonstrated the highest resolving power ever achieved. In this review we summarize latest achievements in theory and simulation of FT ICR mass spectrometers. © 2014 Wiley Periodicals, Inc. Mass Spec Rev 35:219–258, 2016.

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