Article

Cell sheet engineering: intelligent polymer patterned surfaces for tissue engineered liver

  1. Masami Harimoto,
  2. Masayuki Yamato,
  3. Akihiko Kikuchi,
  4. Teruo Okano

Article first published online: 3 JUL 2003

DOI: 10.1002/masy.200390127

Issue

Macromolecular Symposia

Macromolecular Symposia

Special Issue: Progress in Polymer Science and Technology

Volume 195, Issue 1, pages 231–236, July 2003

Additional Information

How to Cite

Harimoto, M., Yamato, M., Kikuchi, A. and Okano, T. (2003), Cell sheet engineering: intelligent polymer patterned surfaces for tissue engineered liver. Macromolecular Symposia, 195: 231–236. doi: 10.1002/masy.200390127

Author Information

  1. Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 162-8666, Japan, Fax: (+81) 3-3359-6046

Publication History

  1. Issue published online: 3 JUL 2003
  2. Article first published online: 3 JUL 2003

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Keywords:

  • cell sheet;
  • co-culture;
  • hepatocyte;
  • poly (N-isopropylacrylamide);
  • temperature-responsive culture surface

Abstract

We describe a new culture system utilizing the temperature-responsive polymer grafted surface for designing of cell position and layered tissue reconstruction. Organizing of the hepatic tissue structure by controlling the culture system, that is patterned co-culture and layered cell sheet co-culture achieved by moving the cultured cells from the culture surface, resulted in regulation of the hepatocyte function. The technique for cell sheet manipulation would promote the liver tissue engineering in quality.

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