Article

Effects of Polymer Modification of an Anti-Cancer Drug with Poly(ethylene oxide)

  1. Jung-Sun Sohn1,
  2. Byung-Wook Jo1,
  3. Michael Hess2,
  4. Kirsten Schwark2,
  5. Stephanie Dehne2,
  6. Manfred Zähres2

Article first published online: 2 JUN 2005

DOI: 10.1002/masy.200550704

Issue

Macromolecular Symposia

Macromolecular Symposia

Special Issue: Polymers in Novel Applications

Volume 225, Issue 1, pages 31–42, May 2005

Additional Information

How to Cite

Sohn, J.-S., Jo, B.-W., Hess, M., Schwark, K., Dehne, S. and Zähres, M. (2005), Effects of Polymer Modification of an Anti-Cancer Drug with Poly(ethylene oxide). Macromol. Symp., 225: 31–42. doi: 10.1002/masy.200550704

Author Information

  1. 1

    Department of Polymer Engineering and Science and Department of New Materials in Biology, Chosun University, 375, Seosok-dong, Dong-gu, KwangJu, 501-759, South Korea

  2. 2

    Department of Physical Chemistry, University Duisburg-Essen, Campus Duisburg, 47048 Duisburg, Germany

Publication History

  1. Issue published online: 2 JUN 2005
  2. Article first published online: 2 JUN 2005

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Keywords:

  • mPEG-paclitaxel;
  • simulation;
  • solution;
  • structure

Abstract

The hydrophobic anti-cancer drug paclitaxel was modified with the hydrophilic poly(ethylene oxide) to a water-soluble predrug. The modification of the polymer chain results in a different solution behaviour of the macromolecules compared with the unmodified polymer. The phase diagram of the (quasi)binary system predrug-water was investigated, and molecular simulations of the predrug were executed in vacuum and in the presence of water. The results are important for further engineering on active drug systems.

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