Article

Preparation and Characterization of Magnetic Targeted Drug Controlled-Release Hydrogel Microspheres

  1. Jie Chen1,
  2. Liming Yang1,
  3. Yinfeng Liu2,
  4. Guowei Ding3,
  5. Yong Pei1,
  6. Jian Li1,
  7. Guofei Hua2,
  8. Jian Huang3

Article first published online: 2 JUN 2005

DOI: 10.1002/masy.200550706

Issue

Macromolecular Symposia

Macromolecular Symposia

Special Issue: Polymers in Novel Applications

Volume 225, Issue 1, pages 71–80, May 2005

Additional Information

How to Cite

Chen, J., Yang, L., Liu, Y., Ding, G., Pei, Y., Li, J., Hua, G. and Huang, J. (2005), Preparation and Characterization of Magnetic Targeted Drug Controlled-Release Hydrogel Microspheres. Macromol. Symp., 225: 71–80. doi: 10.1002/masy.200550706

Author Information

  1. 1

    Department of Chemical Engineering and Technology, Shanghai University (Jiading Campus), Shanghai 201800, China

  2. 2

    Department of Polymer Materials, Shanghai University (Jiading Campus), Shanghai 201800, China

  3. 3

    Tongji Hospital, Tongji University, Shanghai 200065, China

Publication History

  1. Issue published online: 2 JUN 2005
  2. Article first published online: 2 JUN 2005

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Keywords:

  • Bleomycin;
  • hydrogel;
  • magnetic particle;
  • microsphere;
  • PVP;
  • VX2

Abstract

Magnetic targeted drug controlled release hydrogel microspheres were prepared by a radiation technique. Ferric oxide granules (size around 50 nm) were used as the core for magnetic target. The PVP ferrogels (ferromagnetic nanoparticles in hydrogel microsphere) were obtained by irradiating an emulsion of Poly (N-vinylpyrrolidone) PVP/ferromagnetic granule with cobalt 60 γ–ray. The morphology of the PVP ferrogel was studied by both optical and electronic microscopy, respectively. A broad-spectrum anticancer drug, Bleomycin A5 Hydrochloride (BLM), was immobilized in the ferrogel and the release property of the drug in vitro was studied. The function of targeting and anti-cancer was studied on the New Zealand White rabbits, based on the implantation of experimental VX2 squamous cell carcinoma in the auricles of the rabbits.

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