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Keywords:

  • high performance liquid chromatography (HPLC);
  • inflammation;
  • piroxicam;
  • polyurethanes;
  • t-methylimidazole acetic acid

Abstract

Summary: The anti-inflammatory effect of piroxicam (Px) immobilized on a polyurethane (PU) matrix was studied in vivo by measuring levels of t-methylimidazole acetic acid (t-MeImAA) in urine of experimental animals. Released into body from the polymeric matrix, Px affected inflammation process, significantly reducing the t-MeImAA levels. The retention of Px within the PU/drug system – largely due to physical modification of the polymer – resulted in durable therapeutic action of the system.