Innovative Cross-Linked Polyurethane Networks Based on Cyclodextrins and Polyethylene Glycols: Inclusion Capacity and Potential Use as Controlled Release Carrier for Nifedipine

Authors

  • Márcia Valéria Gaspar de Araújo,

    Corresponding author
    1. Laboratory of Synthetic Polymers, Postgraduate Program in Chemistry, Department of Chemistry, Federal University of Paraná, Centro Politécnico Jardim das Américas, 81531-990, Curitiba, Paraná, Brazil
    • Fax: +55 41 33613186
    Search for more papers by this author
  • João Victor Francisco Vieira,

    1. Laboratory of Synthetic Polymers, Postgraduate Program in Chemistry, Department of Chemistry, Federal University of Paraná, Centro Politécnico Jardim das Américas, 81531-990, Curitiba, Paraná, Brazil
    Search for more papers by this author
  • Thiago Alessandre da Silva,

    1. Laboratory of Synthetic Polymers, Postgraduate Program in Chemistry, Department of Chemistry, Federal University of Paraná, Centro Politécnico Jardim das Américas, 81531-990, Curitiba, Paraná, Brazil
    Search for more papers by this author
  • Tatiana Kubota,

    1. Laboratory of Synthetic Polymers, Postgraduate Program in Chemistry, Department of Chemistry, Federal University of Paraná, Centro Politécnico Jardim das Américas, 81531-990, Curitiba, Paraná, Brazil
    Search for more papers by this author
  • Fernanda Malaquias Barboza,

    1. Laboratory of Pharmaceutical Products, Postgraduate Program in Pharmaceutical Science, Department of Pharmaceutical Sciences, State University of Ponta Grossa, Campus Uvaranas, 84030-900, Ponta Grossa, Paraná, Brazil
    Search for more papers by this author
  • Paulo Vitor Farago,

    1. Laboratory of Pharmaceutical Products, Postgraduate Program in Pharmaceutical Science, Department of Pharmaceutical Sciences, State University of Ponta Grossa, Campus Uvaranas, 84030-900, Ponta Grossa, Paraná, Brazil
    Search for more papers by this author
  • Sônia Faria Zawadzki

    1. Laboratory of Synthetic Polymers, Postgraduate Program in Chemistry, Department of Chemistry, Federal University of Paraná, Centro Politécnico Jardim das Américas, 81531-990, Curitiba, Paraná, Brazil
    Search for more papers by this author

Abstract

Summary: Polymers derived from cyclodextrins show several biomedical applications. In this paper, six cross-linked polyurethane networks based on β-cyclodextrin (βCD) or hydroxypropyl-β-cyclodextrin (HPβCD) and polyethylene glycols (PEG 400, PEG 1500 or PEG 4000) were synthesized by the usual two-step polymerization method. The polymers were characterized by Fourier-transformed infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and X-ray diffraction (XRD). The inclusion capacity was evaluated by the discoloration method of a phenolphthalein solution. In order to explore their potential use as controlled drug delivery systems, dissolution profiles and release behavior of inclusion complexes between PUR/TDI/βCD/PEG4000 or PUR/TDI/HPβCD/PEG1500 and nifedipine (NIF) were investigated. FTIR assignments confirmed the formation of urethane linkages. XRD patterns revealed that the crystallinity decreased mainly due to the crosslinking process. TGA showed three stages of mass loss attributed to water loss, cleavage of urethane bonds and volatilization of decomposition products. The inclusion capacity of cyclodextrins cross-linked with polyurethane was suitably maintained. Dissolution profiles demonstrated that the inclusion complexes PUR/TDI/βCD/PEG4000-NIF and PUR/TDI/HPβCD/PEG1500-NIF are feasible systems for controlling drug release, showing a biexponential release behavior.

Ancillary