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In Situ Incorporation of Doxorubicin in Copolymer Particles During Suspension Polymerization

Authors

  • Marco Antonio M. Oliveira,

    1. Programa de Engenharia Química/COPPE, Universidade Federal do Rio de Janeiro, Cidade Universitária – CP: 68502, Rio de Janeiro, 21945-970 RJ, Brazil
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  • Príamo A. Melo Jr.,

    1. Programa de Engenharia Química/COPPE, Universidade Federal do Rio de Janeiro, Cidade Universitária – CP: 68502, Rio de Janeiro, 21945-970 RJ, Brazil
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  • Márcio Nele,

    1. Programa de Engenharia Química/COPPE, Universidade Federal do Rio de Janeiro, Cidade Universitária – CP: 68502, Rio de Janeiro, 21945-970 RJ, Brazil
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  • José Carlos Pinto

    Corresponding author
    1. Programa de Engenharia Química/COPPE, Universidade Federal do Rio de Janeiro, Cidade Universitária – CP: 68502, Rio de Janeiro, 21945-970 RJ, Brazil
    • Fax: +55 21 2562 8337
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Abstract

Summary: This work reports the kinetic behavior and the molecular properties of obtained copolymers during vinyl acetate and methyl methacrylate suspension copolymerizations in presence of doxorubicin. The obtained spherical particles are intended for use as chemoembolization agents. It is shown that the presence of doxorubicin in the reaction medium promotes significant changes in the copolymerization kinetics and final molecular weight averages of the polymer product.

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