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Synthesis and Study of New Copolymers Capable of Forming Molecular Complexes with DNA

Authors

  • N.K. Davydova,

    Corresponding author
    1. A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences, Vavilova St. 28, Moscow, V-334, 119991 Russia
    • A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences, Vavilova St. 28, Moscow, V-334, 119991 Russia, Fax: +7-499-135-50-85.
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  • O.V. Sinitsyna,

    1. A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences, Vavilova St. 28, Moscow, V-334, 119991 Russia
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  • I.V. Yaminsky,

    1. A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences, Vavilova St. 28, Moscow, V-334, 119991 Russia
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  • E.V. Kalinina,

    1. A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences, Vavilova St. 28, Moscow, V-334, 119991 Russia
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  • K.E. Zinoviev

    1. Institute for Microelectronics of Barcelona, (IMB-CNM, CSIC), Cerdanyola del Vallès, Barcelona, E-08193, Spain
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Abstract

Summary: The possibility of creating the copolymers capable of specific interactions with DNA was studied. The copolymers of acrylamide and synthesized N-substituted acrylamides were obtained by free-radical copolymerization in aqueous medium. Using atomic force microscopy it was demonstrated that some of the obtained copolymers form molecular complexes with the bacteriophage lambda DNA. Potentially, the copolymers can be used for detection of DNA in sensing applications.

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