Synthesis of Model Network Hydrogels via Tetrazine-Olefin Inverse Electron Demand Diels-Alder Cycloaddition

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Summary

The formation of poly(etheylene glycol) (PEG) model network hydrogels via an A2 + B3 inverse-electron-demand tetrazine-olefin Diels-Alder cycloaddition is reported. This method provides an efficient, additive-free, colorimetric gelation reaction that will complement other “click chemistry” approaches to model network synthesis.

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