Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni
Article first published online: 25 JUL 2014
© 2014 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 3, Issue 5, pages 702–710, October 2014
How to Cite
MicrobiologyOpen 2014; 3(5): 702–710
- Issue published online: 9 OCT 2014
- Article first published online: 25 JUL 2014
- Manuscript Accepted: 27 JUN 2014
- Manuscript Revised: 17 JUN 2014
- Manuscript Received: 18 MAR 2014
- Searle Scholar program
- Burroughs-Wellcome Fund Career Award for the Biological Sciences
- Howard Hughes Medical Institute
- Beckman Center at Caltech
- Campylobacterales ;
- cryoelectron tomography;
- food poisoning;
- polyphosphate storage granules
Campylobacter jejuni is one of the most successful food-borne human pathogens. Here we use electron cryotomography to explore the ultrastructure of C. jejuni cells in logarithmically growing cultures. This provides the first look at this pathogen in a near-native state at macromolecular resolution (~5 nm). We find a surprisingly complex polar architecture that includes ribosome exclusion zones, polyphosphate storage granules, extensive collar-shaped chemoreceptor arrays, and elaborate flagellar motors.