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Figure S1. Gelatin zymography of the LAC wild-type and its protease-null mutant.

Figure S2. Exoprotease deletion does not lead to observable difference in agr or hla transcript levels.

Figure S3. Western blot analysis confirms increased abundance of select surface and secreted virulence factors upon exo-protease deletion.

Figure S4. Exoprotease deletion leads to increased α-hemolysin activity.

Figure S5. Secreted proteolytic activity of clinical S. aureus isolates.

Table S1. Collective alterations in protein abundance for secreted proteins upon deletion of extracellular proteases in S. aureus USA300.

Table S2. Individual fraction analysis of alterations in protein stability for secreted proteins upon deletion of extracellular proteases in S. aureus USA300.

Table S3. Collective alterations in protein abundance for surface proteins upon deletion of extracellular proteases in S. aureus USA300.

Table S4. Individual fraction analysis of alterations in protein stability for surface proteins upon deletion of extracellular proteases in S. aureus USA300.

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