Correlation of p27 protein expression with HER-2/neu expression in breast cancer
Article first published online: 6 APR 2001
Copyright © 2001 Wiley-Liss, Inc.
Volume 30, Issue 3, pages 169–175, March 2001
How to Cite
Newman, L., Xia, W., Yang, H.-Y., Sahin, A., Bondy, M., Lukmanji, F., Hung, M.-C. and Lee, M.-H. (2001), Correlation of p27 protein expression with HER-2/neu expression in breast cancer. Mol. Carcinog., 30: 169–175. doi: 10.1002/mc.1025
- Issue published online: 6 APR 2001
- Article first published online: 6 APR 2001
- Manuscript Accepted: 6 DEC 2000
- Manuscript Revised: 13 NOV 2000
- Manuscript Received: 18 AUG 2000
- human epidermal growth factor receptor 2/neu;
- breast cancer
Strong expression of human epidermal growth factor receptor 2 (HER-2)/neu in breast cancer has been associated with poor prognosis. Reduced expression of p27Kip1, a cyclin-dependent kinase inhibitor, correlates with poor clinical outcome in breast cancer. In this study, we provide a correlation between these two important prognostic markers in patients with breast cancer. Breast tumor screening using immunohistochemistry indicated that downregulation of p27 correlated with HER-2/neu overexpression in studying 11 normal breast tissues and 51 primary breast carcinomas. We found HER-2/neu protein overexpression in 20 (41%) of 49 breast cancers and low p27 protein expression in 47 (92%) of 51 breast cancers. All 20 (100%) of the tumors that overexpressed HER-2/neu had low levels of p27 protein product; this correlation was statistically significant (P = 0.035). Decreasing p27 expression correlated with increasing HER-2/neu activity. Our results suggest that one function of the HER-2/neu product is to downregulate p27 expression in breast cancer. This study may be significant in selecting patients for HER-2/neu antibody therapy in the future. Mol. Carcinog. 30:169–175, 2001. © 2001 Wiley-Liss, Inc.