Genomic instabilities in squamous cell carcinoma of head and neck from the Indian population
Article first published online: 9 JAN 2006
Copyright © 2006 Wiley-Liss, Inc.
Volume 45, Issue 4, pages 270–277, April 2006
How to Cite
Chakrabarti, S., Sengupta, S., Sengupta, A., Basak, S. N., Roy, A., Panda, C. and Roychoudhury, S. (2006), Genomic instabilities in squamous cell carcinoma of head and neck from the Indian population. Mol. Carcinog., 45: 270–277. doi: 10.1002/mc.20178
- Issue published online: 10 MAR 2006
- Article first published online: 9 JAN 2006
- Manuscript Accepted: 28 NOV 2005
- Manuscript Revised: 17 NOV 2005
- Manuscript Received: 9 AUG 2005
- HNSCC tumors;
Intrinsic genomic instability of an incipient tumor cell drives the development of cancer. In colorectal cancer, an inverse relationship between microsatellite instability (MIN) and chromosomal instability (CIN) has been reported. The relationship between MIN and CIN in head and neck squamous cell carcinoma (HNSCC) is uncertain. In the present study, we examined these two types of instabilities in HNSCC using microsatellite markers and arbitrary primed PCR (APPCR) technique. HNSCC tumors showed high frequency of MIN and loss of heterozygosity (LOH). We observed that, in contrast to colorectal tumors, the frequency of LOH increased with the increase in MIN. There was no significant difference between MIN− and MIN+ groups of HNSCC tumors in the extent of overall genomic alterations; rather higher MIN+ tumors exhibited higher incidence of deletion. Thus, in sporadic HNSCC, both MIN and CIN pathways operate simultaneously to drive tumor formation. © 2006 Wiley-Liss, Inc.